The side effects on sema are fairly unpleasant and it’s action is more limited than the other 2 options.

Sema is the poor man’s/council estate mum option. The spoons fry up if you will.

Tirz is like going to the Ivy.

Reta is the Michelin star of weight loss jabs.

 

Seems a bit harsh, I'm still using sema, only because I bought a load of it last year though. The only side effect I have is bloody tinnitus.

I might sell what I have left and try reta.

 

Did you buy sema at its peak price?

 

sema is the old outdated glp. Reta is leaps and bounds ahead of sema. Everyone’s just getting with the times now. Also, sema carry’s a charge as it’s a prescription only med now, same tirz, Reta is still a research Chem 😎👍

 

Well that's a bit rubbish then, means I can't legally sell the stuff I have!

 

Yeah experimented with sema twice and just couldn't get on with it. Its like using a sledgehammer to put up a picture! Did nothing to curb my appetite (not convinced anything can tbf) but absolutely wrecked my digestion and stayed awful for weeks after cessation.

First time followed the protocol exactly and was essentially squirting from the arse for two weeks. Finally settled but just felt crap.

Second time, halved the standard protocol and got more of the same.

Not for me. 🤣

Like the guys have said, its rather outdated now. The only prescribed people I know personally are being prescribed tirz instead.

 

Good analogy!

 

One is a triple action the other is not, one kills your appetite the other does that to a lesser extent so you can hit your macros but also actually burns fat and sorts out lipids and insulin sentivty so its a no brainer

 

So does reta not have as much of an effect on appetite?

 

no, you still want to eat and are hungry just no desire for junk food making it ideal for body builders to hit their macors and not jsut fat susan who doesnt want to eat and loose weight fat and muscle at all costs

 

The weight loss really starts when you develop thyroid cancer.

 

Would you have any studies I could have a look over where this is the case in human studies?

https://pmc.ncbi.nlm.nih.gov/articles/PMC11202033/

 

I think I might get a single bottle of reta from a UK source and give it a try. My weight loss has slowed right down, and I'm not keen on upping the sema dose.

 

There's another decent one on trial in America, by all accounts, it will make Reta the same way as Semaglutide, (redundant).

 

What refinement are they after with these later generations of GLP1 agonists if they're already so low side effect and blunting appetite in a dose dependent manner?

 

Cagrilintide? (Sp?)

I’ve seen it on source lists but I’ve never investigated further.

 

Anyone else get the massive constipated shits on reta?

Every shite feels like giving birth to a guinea pig. I will increase fibre exponentially.

 

i’ve a lot of oats and berries with seeds in when i make a overnight bowl and other high fibre foods so I haven’t found that but seems an issue for those who do eat a poor diet without fiber and other nutrient dense foods

 

Good question I've noticed the same trend. It seems like some of the buzz around semaglutide has shifted as newer compounds like retatrutide and tirzepatide are getting more attention. Maybe it's down to faster results or fewer side effects being reported, but I think semaglutide still has a solid place depending on individual response. Would be interesting to hear if others have switched or stuck with it long-term. https://www.uk-muscle.co.uk/threads...o.uk/threads/semaglutide-retatrutide-tirzepatide.375670/?utm_source=chatgpt.com