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Retatrutide dosing/experience

4K views 60 replies 13 participants last post by  AcostaGabriel  
#1 ·
Running Retatrutide at 3 x 1mg weekly.

After researching a bit heard this might be the best way to avoid any side effects rather than a single weekly dose.

1st June I was 101kg

Today I weighed in at 95.6kg

Obviously that’s mainly water etc, but my question is how have you guys found it at these doseages?

I’ve only done 2 injections, Sunday and yesterday but I wouldn’t say I’ve noticed a lot, I’m dropping weight as I usually would whilst starting a cut

I wouldn’t say my appetite has reduced, may take some time for it to build up.

anyone tried splitting it through the week?
 
#6 ·
Started on 2, then did 3mg every 5 days for 30 days.

Just started a new vial, will do 2.5mg every 5 days for 40 days. Currently 15.6lb down on Day 1.

Probably my new favourite chemical.
 
#20 ·
@Uptonogood @Tricky

Do you find the split dose much better then?

Mrs is using tirzepatide and finding that the back end of the week, her hunger (feeling full) is almost normal again.
I used to take Monday morning upon waking. i would notice by Thursday and most def Friday on I was hungry and didnt feel any supression. Ive now split to Mon and Thur and its much easier over the weekend.
 
#19 ·
Every 5 days is the one. Day 4 it sneaks back in so you ride it out and then Day 5 rejab.

Works well and there's a bit of overlap on the active time period, the name escapes me
 
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#30 ·
Id suggest either your Semi dosing was to low or it was bunk then as Semi hits like a tonne of bricks and is horrible, I couldn’t even get my protein in.

Reta is brilliant, I can still eat and enjoy my food, I’ve lost 12kg in 27 days, not had one craving for anything outside of my diet, literally sat across from my wife whilst she ate kfc, pizza and cake etc and eaten my chicken and rice happily.

it’s genuinely a brilliant compound and for someone like me with a big appetite, had made dieting an absolute breeze.

im only running 1 mg split into 3 doses tues, thurs, sat.

game changer and unlikely some people saying that to push sales, I’m talking genuine first hand experience.

hope this helps
 
#34 ·
Appetite suppression comes in within a couple of hours for me. Generally lasts for 4/5 days after a jab and then I start getting hungry again. I jab every 5th day now as it’s cheap enough if you buy it at bulk prices.
 
#37 · (Edited)
Been on Reta since 2nd July, started diet Mon 30 June at 77kg.

Went from 71.5kg (carb depleted) in April pre-holiday to 77kg (although that was only for one day) because I couldn't stick to my diet.

First dose was 2mg. Woke up the next day less hungry and with less appetite in the afternoon, it picked up later in the day. Was like that for Thursday, Friday and Saturday.

Went from poor diet adherence and a couple of takeaways a week to 100% diet adherence. I always say the first two weeks of a diet are the hardest as you adjust to denying yourself nice food and wait for the results to show, but this was instant. The voice on your shoulder telling you to have a cheat meal, you need a refeed, or to eat a donut IIFYM is non-existent.

Found hunger rising after day 5-6 so redosed 2.5mg early, then did it again 6 days later. Most recent dose was 3.5mg.

I've gone from 76 to 71.9kg. My weight loss is almost entirely flat linear and I'm down in weight most days. Think there's been 2-3 days max where my weight went up a bit - unlike a normal diet where a) there's constant fluctuations due to water/sodium retention and b) the weight loss can take several days to show on scale.

I haven't increased steps past 10k like I would normally do pre-holiday. Nor have i actually cut calories that much - I'm still eating 1900-2000 despite the hunger suppression. This is most likely because for several months I've been getting my meals prepped from the same place and I'm totally fatigued with their menu, just couldn't bring myself to eat another one of their 450 cal/40g protein or 750 cal/70g protein meals.

70kg is my "photoshoot" weight and I said I'd never get that low again due to the extreme effort it took - eg pushing steps past 20k daily and pushing to brink of exhaustion - however, at this rate of weight loss and ease then I think I'll get there easily in 2 weeks or less.

My withings scales do say I'm holding less water despite not cutting carbs.

If I get to 70kg then I will honestly think reta is a true gamechanger. I see no reason to use clen/t3 if it is this easy with Reta. This is the fastest and easiest I've ever cut and I'm genuinely a "permacutter" who aborts bulks prematurely to get abs back.



SIDE EFFECTS

ok this is actually huge - I wake up every couple of hours at night, usually to pee. This is very annoying. I also have patches of skin that feel sunburnt

Below you can clearly see my without reta cut progress for the holiday in April, the post holiday weight gain with atttempts to cut/reset and when I started the reta

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#38 ·
Been on Reta since 2nd July, started diet Mon 30 June at 77kg.

Went from 71.5kg (carb depleted) in April pre-holiday to 77kg (although that was only for one day) because I couldn't stick to my diet.

First dose was 2mg. Woke up the next day less hungry and with less appetite in the afternoon, it picked up later in the day. Was like that for Thursday, Friday and Saturday.

Went from poor diet adherence and a couple of takeaways a week to 100% diet adherence. I always say the first two weeks of a diet are the hardest as you adjust to denying yourself nice food and wait for the results to show, but this was instant. The voice on your shoulder telling you to have a cheat meal, you need a refeed, or to eat a donut IIFYM is non-existent.

Found hunger rising after day 5-6 so redosed 2.5mg early, then did it again 6 days later. Most recent dose was 3.5mg.

I've gone from 76 to 71.9kg. My weight loss is almost entirely flat linear and I'm down in weight most days. Think there's been 2-3 days max where my weight went up a bit - unlike a normal diet where a) there's constant fluctuations due to water/sodium retention and b) the weight loss can take several days to show on scale.

I haven't increased steps past 10k like I would normally do pre-holiday. Nor have i actually cut calories that much - I'm still eating 1900-2000 despite the hunger suppression. This is most likely because for several months I've been getting my meals prepped from the same place and I'm totally fatigued with their menu, just couldn't bring myself to eat another one of their 450 cal/40g protein or 750 cal/70g protein meals.

70kg is my "photoshoot" weight and I said I'd never get that low again due to the extreme effort it took - eg pushing steps past 20k daily and pushing to brink of exhaustion - however, at this rate of weight loss and ease then I think I'll get there easily in 2 weeks or less.

My withings scales do say I'm holding less water despite not cutting carbs.

If I get to 70kg then I will honestly think reta is a true gamechanger. I see no reason to use clen/t3 if it is this easy with Reta. This is the fastest and easiest I've ever cut and I'm genuinely a "permacutter" who aborts bulks prematurely to get abs back.



SIDE EFFECTS

ok this is actually huge - I wake up every couple of hours at night, usually to pee. This is very annoying. I also have patches of skin that feel sunburnt
I havent got any skin senstivity but I agree I wake up to pee 2-3 times every night other than that no sides for me at all. Been on 13 weeks come monday and will be upping my dose now again at the 4-5mg is doing little in terms of food noise. I plan to max out on 9mg have around 6 weeks max amybe 4 to hit my goal of 3 stone down and get the fat of lower sides and back. So far for me its been remarkable where t3 makes me hungry and I cant tolerate clen above 60mcg.
 
#39 ·
I've also found I'm waking up in the night a lot. Sometimes it's to go to the toilet and sometimes it's just random and I stay awake for an hour and can't get back to sleep. Not ideal for training obviously but the benefits are far outweighing the negative because even with perfect sleep and the related improved training, I wouldn't be losing as much as I am now.
 
#44 ·
I’ve stopped drinking after my evening meal about half 6.

Still usually have to get up once in the night but I suppose that’s my life now I’m middle aged.
 
#45 ·
70.2kg now, have used up the full 20mg vial in 25 days as I was chasing the peak hunger suppression of the first few days so redosing every 5-6 days and increasing dosage sooner.

No point in keeping it 2.5mg with the rate of weight loss, because I'd end up at 70kg with half the vial left.

I have a DEXA booked for Thursday. This weekend is the only weekend where LISS walking was a struggle, also felt flat and hard to get a pump in gym. Definitely could use a refeed but would rather squeeze out the maximum loss pre-dexa
 
#46 ·
It is a pretty mental compound to be fair, I’ve lost 19kg in about 8 weeks. I’ve having to back off the diet for a bit as I’m around 10% body fat but my skin can’t keep up with the weight loss, it looks ridiculous to be honest. I’m also finding it really hard to fill back out, I had a refeed this weekend and it was barely noticeable. I have only gone upto 4mg split over 3 injections weekly.
 
#48 ·
I’m losing it everywhere but my bottom 2 abs and it’s fooking me right off. It’s crawling in at a glacial speed there and melting off everywhere else. Wish I could be one of them ****s who can have abs at 15% bf

Just done another 4mg with 2iu hgh. Should be good for eating until Friday now.

Another 6 weeks should see me right.
 
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#49 ·
I’m losing it everywhere but my bottom 2 abs and it’s fooking me right off. It’s crawling in at a glacial speed there and melting off everywhere else. Wish I could be one of them ****s who can have abs at 15% bf

Just done another 4mg with 2iu hgh. Should be good for eating until Friday now.

Another 6 weeks should see me right.
I’m the same and currently on 8mg but this week i’m trying a new approach 3mg mon, wed,fri and getting off it all in 4 weeks to start at lean bulk. Well maybe taper down to 2mg not sure what’s best yet but have some lower back and lower stubborn ab fat to shift
 
#50 ·
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I've finished my reta experiment as a lean individual starting in category one and as someone who almost definitely shouldn't have needed it to begin with.

43 - 5'11

starting 76kg/167lbs -> 69.9kg / 154lbs in 25 days

My last dexa was Oct 24 74kg 10%

I've tried to include as much data as possible to support this anecdotal journey.

The TLDR is that I reached a weight that:

a) I wasn't planning on reaching
b) I said I'd never go this low again
c) without really trying

70kg was my weight when I had a photoshoot in 2021 (I documented that journey in this group as well), using clen, t3, yohimbine and ECA. I remember pushing myself to brink of exhaustion e.g being unable to jog/dash across a pedestrian crossing that was just about to go from green to red. (although that was less of a cut, more of a trim)
This time - I didn't reduce calories as much and I never increased steps past 10k because I simply didn't need to.

My monthly average was 1930 cals, 158g protein, 68g fat, 143g carbs. Steps weekly average was 86633 - I never aimed to do more than 10k but walk to the gym, supermarket etc

I cut Jan-April for a holiday, increased steps and went VLC in the final fortnight. Then went from 73kg to 76kg in May-July due to poor diet adherence, frequent takeaways etc.

Without external motivation I struggle, which was one reason to give reta a go.

I've never used any GLP-1 previously.

My first dose was 2mg on 2nd July and I had considerably less morning and afternoon hunger for the first 3 days, with appetite returning slightly in the evening

I am willing to chalk this up to a combination of placebo, the retatrutide and also fatigue with my meal prep company. On day 4 I was out of prepped meals and had a desire for less bland food without a craving for junk options.
I decided to take the second dose of 2.5mg on day 5 because I was feeling hungrier (but not as hungry as pre-reta) in the morning, I then continued to redose every 5 days and started to increase the dose as well. I used up the 20mg vial this weekend

This was partly due to:

a) "chasing the dragon" of that initial peak hunger suppression
b) the rate at which I was losing weight meant I'd be at or past my goal weight with half a vial leftover if I stuck to 2.5mg doses

The scale graph speaks for itself. I've never had a cut that was almost a straight line down with barely any fluctuations. I was waking up nearly every day lighter than the prev day. 3 days out of last 28 were up slightly but then back down the following and 19/25 were lower.

My withings scales say I'm holding 2kg less water weight, which is what I'd expect to drop if I went low carb.
So:

Mild hunger suppression. It was enough to not go to bed hungry or be tempted for late night snacks, takeaway orders etc.
Instant diet adherence and killed cravings: Ihe first two weeks of a diet are hardest for me, ignoring the cravings etc until the results on scale start to show. I went from two takeaways a week to zero and had zero thoughts about swapping rice for a donut IIFYM etc

I have a can of sugar-free monster every morning with breakfast and buy a few 2 litre bottle of pepsi max a week, or a few 500ml bottles occasionally. I had zero desire or thoughts about pepsi this whole time

Is there a metabolic advantage with reta?

Based on this experience in contrast with my other cuts I would say yes - However, I was clearly laser dialled in and super consistent. I wasn't just trying to cut, I was trying to evaluate its potential as much as possible. If my food didn't have the exact nutrition information I didn't eat it - there was only 2-3 meals on the road where I only had calorie info.

I could have gone to 1500-1600 calories but I don't think I needed to. The aforementioned meal fatigue meant I was being lazy and eating things like air fryer chicken strips/chicken thighs instead of chicken breast and rice.

I can't recall in much detail my previous cuts except the pre-holiday one, except to say I've done the 20k+ steps a day, the 1500 cals and below, only eating lean protein and salad etc. Normally my stopping point is 72-73kg - perhaps getting lower after going VLC.

It's also worth mentioning I fall into the "permacut" cycle and abort surplus phases prematurely. I probably have some body dysmorphia because in the side by side pictures I'm probably lean enough at 75kg to stay in the surplus

If 2kg was water weight, then I've lost approx 1kg per week with a moderate deficit and a regular amount of exercise

SIDE EFFECTS:

1. Waking up every 2 hours like clockwork to pee - this was super annoying and is the biggest incentive for me to not wholeheartedly endorse reta.

2. HR is up from 60 to 78, and HRV is consistently lower too

3. sunburnt skin feeling

Energy and strength wise I felt fine until this past weekend. Yesterday was first day where my LISS walking was tough and I only did 30 minutes instead of the target 60. This last week my strength regressed and on Saturday I felt flat/hard to get a pump in the gym.

This would normally be where I would have a refeed. I definitely considered it but will save it for later this week as I have a DEXA booked for Thursday

Would I use it again?

The instant adherence is a big plus. But booking a holiday or similar event is usually enough incentive to start adhereing. If I wanted/needed 100% and instant adherence/consistency then it's probably worth it.

I'm curious how a lower weekly dose would support a lean bulk, but not sure if I'm willing to buy more to test and risk more disrupted sleep
 
#51 ·
Detailed post above @famasfilms and points raised show we all react differently to it as i’ve not had the sunburnt feeling others have mentioned and I work two jobs which means mon, tue and fri night I only sleep from
3.30am-7.30am but I still run 60km per week and train 3-4 times a week. So i’ve not felt the fatigue and i’m 14 weeks in.

I milked 2.5mg for the first 4 weeks then went to 4mg split twice weekly for a few weeks then 5mg split again twice a week as I always found that hunger came back within 4-5 days.

I wish I had the suppression of sugar free drinks as i’m a fiend for sugar free monster usually 3 a day and pepsi max. I do take my electrolytes and water throughout the day.

What i’ve found is the desire to snack or eat crap isn’t there and no hunger first 6-8 weeks but since then I could eat 4-5k kcals easy so i’m still needing to be disciplined.

Either way i’m 17kg down, have around 3-4kg left and giving myself until sept to hit it before embarking on a lean bulk which I won’t lie im terrified off as I don’t want to get fat but understand I can’t and wont stay on reta so will go cold turkey i think and lean bulk sept to jan 1st
 
#56 ·
Metele un cagrilintide de ayuda eso te quitará totalmente las ganas de comer y tomar Monster muy poquita dosis menos de 1mg diría que de 1 mg la mitad o aún menos, ya que puedes enfermar y no comer nada!!! Te vendría bien y ademas cagri dura fácilmente 10 dias pero recomendable colocarlo cada semana en el mismo dia que la anterior!!!
 
#53 ·
I'm 30 days in and lost 14.5lb.
Can see the difference but I underestimated how much I needed to lose to get to where I want to be. Thought 20lb loss would have me shredded but think I'll need to get to 30lb loss.
Go on holiday in 18 days so will have to carry on after I get back, which wasn't in the original plan.

Negative side effects are sleeping a lot less and resting heart rate in up about 8bpm.

Unfortunately didn't take any before photos so not as easy for me to judge progress but I'm back on the last hole of my weight lifting belt, which is a bit of an obscure way to measure progress but there you go.
 
#58 ·
Ive been doing 1mg reta every 5 days.

Im on a post diet/maintenance/trt phase and seeing what it brings to the table for insulin sensitivity and cholesterol as ive read that it works wonder for the latter, which i generally struggle to keep in range with good diet and cardio.

Im up from 2300cals on cut to around 3200 currently. Scale weight is not moving just fluctuating around 89kg and appear to be getting leaner especially on abs. Noted appetite supression is not massive like sema but not clamming for shite calories. Its like dieting on higher cals with good strength and performance.

Will do bloods in a couple of weeks and see if its doing the business. Its set me up for a good lean bulk as i generally get fluffy quite fast as soon as i increase calories.
 
#59 ·
Tbf if it sorts out lipids and insulin sensitivity it should theoretically hold that you can diet on slightly higher cals as you wont be throwing out a load of excess insulin every time you have a teaspoon of sugar
 
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#60 ·
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Here's a question.

Why do I look more shredded/peeled on 18 April at 71.9kg before reta, pre holiday than I do at 2.5kg lighter after a 28 day reta cycle?

I didn't cut carbs on reta but my withings scales say I dropped water weight, a similar amount to as if I cut carbs.


I had a Dexa scan this week:

October 24 74.4kg 10.1%
July 25 70.4kg 8.68%

So my fat is down 1.397kg and my lean mass is down 2.5kg - which is what I expected considering my water weight is down. In October 2024 going into the Dexa I was eating in a surplus, hadn't cut carbs - so my food volume in stomach, water etc would be higher


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I'm just curious why I look leaner in April than today. Is it because going zero carb totally dried me out even though the scale water numbers are the same? I am curious if I'd drop even more water weight going low carb with some reta still in my system. Admittedly the 18 April shot was the peak shot of that cut and the photos either side aren't as peeled
 
#61 ·
Definitivamente estas mas delgado con reta , pasa que pareciera del reves por las sombras y calidad de imagen pero si te pones a analizar bien verás distinto a pesar de que con reta tienes mas liquido que deberias sacar y bajarás aun mas de peso alli hay por lo menos 1 kilo de liquido aun oor sacar , ya que reta retiene demasiado liquido!!! Pero demasiado liquido retiene y eso deberias de sacar y luego volver a comparar