myostatin blockers - UK-Muscle Body Building Community

Biker · 27-08-2004, 04:25 PM

anyone used them? are they worth the money? Do they work?

The particular one I have in mind is the Biotest one, in theory and certainly in animal tests blocking myostatin causes a great muscle increase, but do the human versions work?

***Lorian*** · 27-08-2004, 04:42 PM

Quote:

Originally Posted by Biker

anyone used them? are they worth the money? Do they work?

The particular one I have in mind is the Biotest one, in theory and certainly in animal tests blocking myostatin causes a great muscle increase, but do the human versions work?

I havent used them personally due to cost - but if I was then I would choose Biotest Myostat as well.

We do have one customer that religiously buys 2-boxes every couple of months and believes they are working for him.

L

damagedgoods · 27-08-2004, 04:59 PM

From what I have read there is a lot to be said for muscle mass increase when Myosatin is blocked - but so far all the research has been on mice that have been bread to haev a particular genetic sequence to prevent the protein being syntyhisied. THere is a 5year old boy in germany who also has this genetic mutation, and he is said to exhibit signs of having much greater muscle mass, Flex wheeler is also said to have this trait.

At present there are no drugs that are available that will 'block' myosatin, although they are being developed. so I don't knwo how effective supplements are at acheiving this. In fact I'd be so bold as to say that co's that claim to block myosatin are likely to be talking S.H.I.T. as if they could then there woudl be a big demand in the medical industry to treat patients with degenerative disorders such as muscular dstropy. Although if any of you do find a supplement that does in fact do this let me know!

damagedgoods · 27-08-2004, 05:00 PM

here is the article about that boy:

Doctors discover a toddler muscle man
DailyCamera.com ^ | 6/23/04 | Linda A. Johnson

Posted on 06/23/2004 2:49:50 PM PDT by LibWhacker

Somewhere in Germany is a baby Superman, born in Berlin with bulging arm and leg muscles. Not yet 5, he can hold seven-pound weights with arms extended, something many adults cannot do. He has muscles twice the size of other kids his age and half their body fat.

DNA testing showed why: The boy has a genetic mutation that boosts muscle growth.

The discovery, reported in Thursday's New England Journal of Medicine, represents the first documented human case of such a mutation.

Many scientists believe the find could eventually lead to drugs for treating people with muscular dystrophy and other muscle-destroying conditions. And athletes would almost surely want to get their hands on such a drug and use it like steroids to bulk up.

The boy's mutant DNA segment was found to block production of a protein called myostatin that limits muscle growth. The news comes seven years after researchers at Johns Hopkins University in Baltimore created buff "mighty mice" by "turning off" the gene that directs cells to produce myostatin.

"Now we can say that myostatin acts the same way in humans as in animals," said the boy's physician, Dr. Markus Schuelke, a professor in the child neurology department at Charite/University Medical Center Berlin. "We can apply that knowledge to humans, including trial therapies for muscular dystrophy."

Given the huge potential market for such drugs, researchers at universities and pharmaceutical companies already are trying to find a way to limit the amount and activity of myostatin in the body. Wyeth has just begun human tests of a genetically engineered antibody designed to neutralize myostatin.

Dr. Lou Kunkel, director of the genomics program at Boston Children's Hospital and professor of pediatrics and genetics at Harvard Medical School, said success is possible within several years.

"Just decreasing this protein by 20, 30, 50 percent can have a profound effect on muscle bulk," said Kunkel, who is among the doctors participating in the Wyeth research.

Muscular dystrophy is the world's most common genetic disease. There is no cure and the most common form, Duchenne's, usually kills before adulthood. The few treatments being tried to slow its progression have serious side effects.

Muscle wasting also is common in the elderly and patients with diseases such as cancer and AIDS.

"If you could find a way to block myostatin activity, you might slow the wasting process," said Dr. Se-Jin Lee, the Johns Hopkins professor whose team created the "mighty mice."

Lee said he believes a myostatin blocker also could suppress fat accumulation and thus thwart the development of diabetes. Lee and Johns Hopkins would receive royalties for any myostatin-blocking drug made by Wyeth.

Dr. Eric Hoffman, director of Children's National Medical Center's Research Center for Genetic Medicine, said he believes a muscular dystrophy cure will be found, but he is unsure whether it will be a myostatin-blocking drug, another treatment or a combination, because about a dozen genes have some effect on muscles.

He said a mystotatin-blocking drug could help other groups of people, including astronauts and others who lose muscle mass during long stints in zero gravity or when immobilized by illness or a broken limb.

Researchers would not disclose the German boy's identity but said he was born to a somewhat muscular mother, a 24-year-old former professional sprinter. Her brother and three other close male relatives all were unusually strong, with one of them a construction worker able to unload heavy curbstones by hand.

In the mother, one copy of the gene is mutated and the other is normal; the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people.

The boy is healthy now, but doctors worry he could eventually suffer heart or other health problems.

In the past few years, scientists have seen great potential in myostatin-blocking strategies.

Internet marketers have been hawking "myostatin-blocking" supplements to bodybuilders, though doctors say the products are useless and perhaps dangerous.

Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them far more muscle and less fat than other steer.

damagedgoods · 27-08-2004, 05:04 PM

This is a picture of a belgian bull with the myosatin gene mutation.

Greyphantom · 27-08-2004, 05:45 PM

Now thats alot of beef...

**hackskii** · 27-08-2004, 05:55 PM

That looks wild. Deformed.
Look at those traps

Musclehed · 28-08-2004, 09:58 AM

That kid providing all goes well will take the p.i.s.s. at the 2020 olympics, many new records

John · 28-08-2004, 11:08 AM

Quote:

Originally Posted by hackskii

That looks wild. Deformed.
Look at those traps

Look at the front delt

, thats incredible. Do you think if we ate him there would be any chance?:confused: , nah prob not

BSF James · 28-08-2004, 02:38 PM

Blocking myostatin undoubtedly leads to massive muscle growth. However, whether it can be done with blue-green algae (the compound in the myostatin blockers) is not really known for sure. More research needs to be done.

BSF James · 28-08-2004, 02:45 PM

Quote:

Originally Posted by damagedgoods

In fact I'd be so bold as to say that co's that claim to block myosatin are likely to be talking S.H.I.T. as if they could then there woudl be a big demand in the medical industry to treat patients with degenerative disorders such as muscular dstropy

One of my uni projects was on MD and I looked into the work being done to bind myostatin as a possible treatment. They have succeeded in mice but arent even close to humans yet. In mice it took injections directly into the stomach if I remember correctly. They aim to test on dogs next, then monkeys, then humans. Its more difficult the bigger the animal because the immune system is stronger.

With regards to the myostatin blocking supplements, its not 'impossible' that they work, but would be a truly amazing discovery if they do. I'm suprised that the scientists involved in looking myostatin manipulation havent tested them yet and found out for definite if they work or not. Personally to be honest I think its unlikely that a supplement company have triumped where the pharmaceutical industry hasnt given the difference in research funds, but you never know.

winger · 28-08-2004, 06:05 PM

That picture of a belgian bull with the myosatin gene mutation looks so crazy. Here is a pick of the boy.

**hackskii** · 29-11-2006, 06:45 PM

Bump for anyone with any more information on this.

SportDr · 29-11-2006, 08:55 PM

Is the Myostatin blocker selective? I mean if it allowed cardiac muscle to continue growing unchecked that would be dangerous surely.

Found this web page http://www.ast-ss.com/research/cribb...in_3-22-02.asp

Looks like they think its a scam anywho.

SD

winger · 30-11-2006, 03:08 AM

Once again nice post SportDr! ;)

27-08-2004, 04:25 PM	#1 (permalink)
Biker Part of the UK-M furniture... gathering dust in the corner :) Join Date: Apr 2003 Location: Northern Ireland Posts: 3,807	myostatin blockers anyone used them? are they worth the money? Do they work? The particular one I have in mind is the Biotest one, in theory and certainly in animal tests blocking myostatin causes a great muscle increase, but do the human versions work? __________________ -- Biker To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. \| To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. \| To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

27-08-2004, 05:45 PM	#6 (permalink)
Greyphantom Getting HUGE! Join Date: Oct 2003 Location: London Posts: 1,869	Now thats alot of beef... __________________ Greyphantom The Ghost who Grows!!!

27-08-2004, 05:55 PM	#7 (permalink)
hackskii UK-Muscle Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 23,654	That looks wild. Deformed. Look at those traps __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

28-08-2004, 02:38 PM	#10 (permalink)
BSF James BodyShapers Fitness MD Join Date: Sep 2003 Location: Telford Posts: 1,258	Blocking myostatin undoubtedly leads to massive muscle growth. However, whether it can be done with blue-green algae (the compound in the myostatin blockers) is not really known for sure. More research needs to be done. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. -Now with FREE shipping available on all UK mainland orders! 5% off your first order - use discount code ukm6. The #1 choice for To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. with rapid, reliable service. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. - research backed sports nutrition.

29-11-2006, 06:45 PM	#13 (permalink)
hackskii UK-Muscle Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 23,654	Re: myostatin blockers Bump for anyone with any more information on this. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

27-08-2004, 04:59 PM	#3 (permalink)
damagedgoods Looking Freaky Join Date: Oct 2003 Location: Wisbech Posts: 763	From what I have read there is a lot to be said for muscle mass increase when Myosatin is blocked - but so far all the research has been on mice that have been bread to haev a particular genetic sequence to prevent the protein being syntyhisied. THere is a 5year old boy in germany who also has this genetic mutation, and he is said to exhibit signs of having much greater muscle mass, Flex wheeler is also said to have this trait. At present there are no drugs that are available that will 'block' myosatin, although they are being developed. so I don't knwo how effective supplements are at acheiving this. In fact I'd be so bold as to say that co's that claim to block myosatin are likely to be talking S.H.I.T. as if they could then there woudl be a big demand in the medical industry to treat patients with degenerative disorders such as muscular dstropy. Although if any of you do find a supplement that does in fact do this let me know!

27-08-2004, 05:00 PM	#4 (permalink)
damagedgoods Looking Freaky Join Date: Oct 2003 Location: Wisbech Posts: 763	here is the article about that boy: Doctors discover a toddler muscle man DailyCamera.com ^ \| 6/23/04 \| Linda A. Johnson Posted on 06/23/2004 2:49:50 PM PDT by LibWhacker Somewhere in Germany is a baby Superman, born in Berlin with bulging arm and leg muscles. Not yet 5, he can hold seven-pound weights with arms extended, something many adults cannot do. He has muscles twice the size of other kids his age and half their body fat. DNA testing showed why: The boy has a genetic mutation that boosts muscle growth. The discovery, reported in Thursday's New England Journal of Medicine, represents the first documented human case of such a mutation. Many scientists believe the find could eventually lead to drugs for treating people with muscular dystrophy and other muscle-destroying conditions. And athletes would almost surely want to get their hands on such a drug and use it like steroids to bulk up. The boy's mutant DNA segment was found to block production of a protein called myostatin that limits muscle growth. The news comes seven years after researchers at Johns Hopkins University in Baltimore created buff "mighty mice" by "turning off" the gene that directs cells to produce myostatin. "Now we can say that myostatin acts the same way in humans as in animals," said the boy's physician, Dr. Markus Schuelke, a professor in the child neurology department at Charite/University Medical Center Berlin. "We can apply that knowledge to humans, including trial therapies for muscular dystrophy." Given the huge potential market for such drugs, researchers at universities and pharmaceutical companies already are trying to find a way to limit the amount and activity of myostatin in the body. Wyeth has just begun human tests of a genetically engineered antibody designed to neutralize myostatin. Dr. Lou Kunkel, director of the genomics program at Boston Children's Hospital and professor of pediatrics and genetics at Harvard Medical School, said success is possible within several years. "Just decreasing this protein by 20, 30, 50 percent can have a profound effect on muscle bulk," said Kunkel, who is among the doctors participating in the Wyeth research. Muscular dystrophy is the world's most common genetic disease. There is no cure and the most common form, Duchenne's, usually kills before adulthood. The few treatments being tried to slow its progression have serious side effects. Muscle wasting also is common in the elderly and patients with diseases such as cancer and AIDS. "If you could find a way to block myostatin activity, you might slow the wasting process," said Dr. Se-Jin Lee, the Johns Hopkins professor whose team created the "mighty mice." Lee said he believes a myostatin blocker also could suppress fat accumulation and thus thwart the development of diabetes. Lee and Johns Hopkins would receive royalties for any myostatin-blocking drug made by Wyeth. Dr. Eric Hoffman, director of Children's National Medical Center's Research Center for Genetic Medicine, said he believes a muscular dystrophy cure will be found, but he is unsure whether it will be a myostatin-blocking drug, another treatment or a combination, because about a dozen genes have some effect on muscles. He said a mystotatin-blocking drug could help other groups of people, including astronauts and others who lose muscle mass during long stints in zero gravity or when immobilized by illness or a broken limb. Researchers would not disclose the German boy's identity but said he was born to a somewhat muscular mother, a 24-year-old former professional sprinter. Her brother and three other close male relatives all were unusually strong, with one of them a construction worker able to unload heavy curbstones by hand. In the mother, one copy of the gene is mutated and the other is normal; the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people. The boy is healthy now, but doctors worry he could eventually suffer heart or other health problems. In the past few years, scientists have seen great potential in myostatin-blocking strategies. Internet marketers have been hawking "myostatin-blocking" supplements to bodybuilders, though doctors say the products are useless and perhaps dangerous. Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them far more muscle and less fat than other steer.

27-08-2004, 05:04 PM	#5 (permalink)
damagedgoods Looking Freaky Join Date: Oct 2003 Location: Wisbech Posts: 763	This is a picture of a belgian bull with the myosatin gene mutation.

28-08-2004, 09:58 AM	#8 (permalink)
Musclehed Gym Addict Join Date: Feb 2004 Posts: 156	That kid providing all goes well will take the p.i.s.s. at the 2020 olympics, many new records

29-11-2006, 08:55 PM	#14 (permalink)
SportDr Getting HUGE! Join Date: Sep 2004 Location: E-Sussex UK Posts: 2,631	Re: myostatin blockers Is the Myostatin blocker selective? I mean if it allowed cardiac muscle to continue growing unchecked that would be dangerous surely. Found this web page http://www.ast-ss.com/research/cribb...in_3-22-02.asp Looks like they think its a scam anywho. SD __________________ I don't like Sports and I am not a Doctor! You expressed and challenged yourself, startled the dozing muscles and welcomed the sweet pain of gain. Boredom begets mediocrity. Enemies both, they deserve swift eradication. Let's hit the weights and build some muscle. Race ya to the bench press. Dave Draper A goal casually set and lightly taken will be freely abandoned at the first obstacle. Zig Ziglar Any advice given is for information only, always seek the advice of your medical practitioner. Use this My Protein refferer code and get a 5% DISCOUNT on your first order! MP2819 Last edited by SportDr; 29-11-2006 at 08:57 PM.

30-11-2006, 03:08 AM	#15 (permalink)
winger UK-Muscle Male Animal Join Date: Jul 2003 Location: Southern California, USA Posts: 10,324 Blog Entries: 1	Re: myostatin blockers Once again nice post SportDr! ;) __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

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