w_llewellyn

You just reposted the same thing we were taking about.. Only adding to it a study illustrating that abnormal metabolism of AA is noted in certain disease.. Abnormal metabolism of many things is seen with disease, hence the term abnormal metabolism.

Here are some relevant safety studies of AA in humans, in doses similar to or above what we recommend:

Dietary arachidonic acid: harmful, harmless or helpful?
British Journal of Nutrition (2007), 98, 451–453

In conclusion, this new study by Katsumoto et al. adds valuable new information to our knowledge about the impact of increased dietary intake of arachidonic acid11. Taken together with earlier studies12 – 20, this study suggests that, rather than being harmful, moderately increased arachidonic acid intake is probably harmless in healthy adults, although the effect of intakes above 1·5 g/d are not known and the effect of increased intake in diseased individuals is not known. Furthermore, arachidonic acid appears to be an important constituent of infant formulas and in this setting may be helpful in growth, development and health.

***

The effect of dietary arachidonic acid on plasma lipoprotein distributions, apoproteins, blood lipid levels, and tissue fatty acid composition in humans.
Nelson GJ, Schmidt PC, Bartolini G, Kelley DS, Phinney SD, Kyle D, Silbermann S, Schaefer EJ.

Normal healthy male volunteers (n = 10) were fed diets (high-AA) containing 1.7 g/d of arachidonic acid (AA) for 50 d. The control (low-AA) diet contained 210 mg/d of AA. Dietary AA had no statistically significant effect on the blood cholesterol levels, lipoprotein distribution, or apoprotein levels. Adipose tissue fatty acid composition was not influenced by AA feeding. The plasma total fatty acid composition was markedly enriched in AA after 50 d (P < 0.005). The fatty acid composition of plasma lipid fractions, cholesterol esters, triglycerides, free fatty acids, and phospholipid (PL) showed marked differences in the degree of enrichment in AA. The PL plasma fraction from the subjects consuming the low-AA diet contained 10.3% AA while the subjects who consumed the high-AA diet had plasma PL fractions containing 19.0% AA. The level of 22:4n-6 also was different (0.67 to 1.06%) in the plasma PL fraction after 50 d of AA feeding. After consuming the high-AA diet, the total red blood cell fatty acid composition was significantly enriched in AA which mainly replaced linoleic acid. These results indicate that dietary AA is incorporated into tissue lipids, but selectively into different tissues and lipid classes. Perhaps more importantly, the results demonstrate that dietary AA does not alter blood lipids or lipoprotein levels or have obvious adverse health effects at this level and duration of feeding.

***

The effect of dietary arachidonic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans.

Arachidonic acid (AA) is the precursor of thromboxane and prostacyclin, two of the most active compounds related to platelet function. The effect of dietary AA on platelet function in humans is not understood although a previous study suggested dietary AA might have adverse physiological consequences on platelet function. Here normal healthy male volunteers (n = 10) were fed diets containing 1.7 g/d of AA for 50 d. The control diet contained 210 mg/d of AA. Platelet aggregation in the platelet-rich plasma was determined using ADP, collagen, and AA. No statistical differences could be detected between the aggregation before and after consuming the high-AA diet. The prothrombin time, partial thromboplastin time, and the antithrombin III levels in the subjects were determined also. There were no statistically significant differences in these three parameters when the values were compared before and after they consumed the high-AA diet. The in vivo bleeding times also did not show a significant difference before and after the subjects consumed the high-AA diet. Platelets exhibited only small changes in their AA content during the AA feeding period. The results from this study on blood clotting parameters and in vitro platelet aggregation suggest that adding 1.5 g/d of dietary AA for 50 d to a typical Western diet containing about 200 mg of AA produces no observable physiological changes in blood coagulation and thrombotic tendencies in healthy, adult males compared to the unsupplemented diet. Thus, moderate intakes of foods high in AA have few effects on blood coagulation, platelet function, or platelet fatty acid composition.

***

Effects of dietary arachidonic acid on human immune response.

Arachidonic acid (AA) is a precursor of eicosanoids, which influence human health and the in vitro activity of immune cells. We therefore examined the effects of dietary AA on the immune response (IR) of 10 healthy men living at our metabolic suite for 130 d. All subjects were fed a basal diet containing 27 energy percentage (en%) fat, 57 en% carbohydrate, and 16 en% protein (AA, 200 mg/d) for the first and last 15 d of the study. Additional AA (1.5 g/d) was incorporated into the diet of six men from day 16 to 65 while the remaining four subjects continued to eat the basal diet. The diets of the two groups were crossed-over from day 66 to 115. In vitro indexes of IR were examined using the blood samples drawn on days 15, 58, 65, 108, 115, and 127. The subjects were immunized with the measles/mumps/rubella vaccine on day 35 and with the influenza vaccine on day 92. Dietary AA did not influence many indexes of IR (peripheral blood mononuclear cell proliferation in response to phytohemagglutinin, Concanavalin A, pokeweed, measles/mumps/rubella, and influenza vaccines prior to immunization, and natural killer cell activity). The post-immunization proliferation in response to influenza vaccine was about fourfold higher in the group receiving high-AA diet compared to the group receiving low-AA diet (P = 0.02). Analysis of variance of the data pooled from both groups showed that the number of circulating granulocytes was significantly (P = 0.03) more when the subjects were fed the high-AA diet than when they were fed the low-AA diet. The small increases in granulocyte count and the in vitro proliferation in response to influenza vaccine caused by dietary AA may not be of clinical significance. However, the lack of any adverse effects on IR indicates that supplementation with AA may be done safely when needed for other health reasons.

w_llewellyn

I think it is probably not a good idea to inject sodium arachidonate into your marginal ear veins. Other than that, I'd direct you to the most relevant safety data I posted above, which involves the oral supplementation of arachidonic acid in similar doses with healthy adult humans for similar periods of time. I don't think it would be possible to produce safety data that is any more relevant or concrete that this..

Truewarrior1

unfortunately i only have the extracts,the papers would cost money i don't have :( , and you'd have to inject a fair amount of air for it to cause an embolism to kill you,and not just more than cellular death!

and it's great that it's PROBABLY harmless.

where do you stand on this then?

"As can be seen in Figure 1, both saturated and omega-6 fats convert to arachidonic acid in the body, whereas the meat itself contains arachidonic acid. One way that the body rids itself of excess arachidonic acid is by producing a dangerous enzyme called 5-lipoxygenase (5-LOX). New studies show conclusively that 5-LOX directly stimulates prostate cancer cell proliferation via several well-defined mechanisms.2,26,30-36 In addition, arachidonic acid is metabolized by 5-LOX to 5-HETE, a potent survival factor that prostate cancer cells utilize to escape destruction.31,37-40" thats an excerpt from the third link i posted.

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TH&S

Is that AA bonded with Salt?

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D: 220 | B: 110 | S: 170 | Target: 550

TH&S

yes but what about in something smaller... say... a rat?

Can you see where I'm coming from? I'm tryign to get past the BS/The Hype/The Hearsay and find the truth.

Not often you have a supplement inventor come on the board.

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D: 220 | B: 110 | S: 170 | Target: 550

Truewarrior1

no i agree mate it ..this just struck me wrong..

"You are also incorrect, in that if you truly found a novel and effective new use for corn oil, you could patent that use. I, however, was not after selling empty promises and marketing hype on something like corn oil, as you so politely have accused me of. I think my time in this industry, my work, and my reputation should speak for itself.. but I guess not around here."

1.i believe we should question everything,no matter the source.
2.he hasn't actually said the difference between corn flour and his supplement
3.he claims to have made 'new technology' to produce this supplement,i'd like to know how it differs from the technology used to extract AA from eggs for baby formulas,which has been around for years prior to his supplement.

4.the supplement industry isn't known for complying with FDA approved contents,what about all these *for now* LEGAL prohormones being being bandered about,it's not as if we haven't had harmful supplements before.

__________________
When You Dance With The Devil You Wait For The Song To Stop.

Currently HULKING OUT!

w_llewellyn

The level of AA in the diet has been shown to have no impact on whether or not you get cancer. It is not a carcinogen. It is a potent growth promoter, however, and like others of this class such as growth hormone, IGF-1, anabolic/androgenic steroids should never be used if you have cancer. These agents may increase the growth of cancer cells like they would normal cells.

TH&S

Yes but I asked that the discussion be continued in a non-defensive manner when it dawned on me who he was, and what the product was. I think it was about my 2nd or third post.

That post was highly defensive, which I wanted to get past and onto some productive discussion.

But yes I agree in questioning everything

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D: 220 | B: 110 | S: 170 | Target: 550

w_llewellyn

1.i believe we should question everything,no matter the source.

Agreed, but you also have to look at the source in determining how credible something is or not.

2.he hasn't actually said the difference between corn flour and his supplement

I don't believe corn flower is anabolic, nor shares the clear association with the anabolic process as I have outlined with arachidonic acid.

3.he claims to have made 'new technology' to produce this supplement,i'd like to know how it differs from the technology used to extract AA from eggs for baby formulas,which has been around for years prior to his supplement.

I never claimed to have made new technology to PRODUCE this supplement. The technology is the discoveries I have made relating to the central role of AA in the anabolic process and its methods for use as a muscle-building anabolic. ANd this is not a patent-pending supplement, but a patented one. The U.S. Patent & Trademark Office agreed that I had developed a novel and pantentable use for AA.

w_llewellyn

We do not sell illegal designer steroids in violation of U.S. law, and AA is not only DSHEA compliant as a dietary supplement but also GRAS approved. I am not sure what the actions of others have to do with our actions?

TH&S

ProHormones aren't supplements though - they are steroids which currently benefit from a loophole in the law giving them legal status.

Bill - just to say thanks for your replies thus far.

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D: 220 | B: 110 | S: 170 | Target: 550

TH&S

Did you mean Corn Oil true - as opposed to Corn Flour?

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D: 220 | B: 110 | S: 170 | Target: 550

w_llewellyn

Just FYI, they do not have legal status. They are considered misbranded drugs in the U.S., and are illegal. The government is just slow to act. No loophole.

No problem. Happy to help.

ah24

Bill, quick question.

I'm looking to compete in natty comps (first one in July) - If I was to experiment with AA could I get pulled up in the drug test?

w_llewellyn

We thus far we have not done any special testing or certification on this, but you shouldn't have any issue. It is made at a GMP certified facility that doesn't work with anabolic steroids, and we've had many natural bodybuilders use it for contest prep with excellent success.

In fact, we've just recently had it used for contest prep by the person that won the Mr. Long Island and Mr. New Jersey titles.