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13-08-2004, 10:51 AM
| #1 (permalink) |
| Newbie Trainer  Join Date: Aug 2004 Location: Scandinavia ____________________________ DISCLAIMER: Chemical Evolution is a fictional Charecter presenting fictional facts, stories & opinions, None of witch should be substetuted for Professional Medical advice! ____________________________
Posts: 13
 | Studies on B6 Effectivness on Prolactin Studies on B6 Effectivness on ProlactinCourtesy of FContact -------------------------------------------------------------------------------- Studies on B6 Effectivness on Prolactin -------------------------------------------------------------------------------- ====================================== J Clin Endocrinol Metab 1976 Mar;42(3):603-6 Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway. Delitala G, Masala A, Alagna S, Devilla L. A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine. =============================== N Engl J Med 1982 Aug 12;307(7):444-5 Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A. ===================================== Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8 [Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects] [Article in Italian] Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C. The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other authors appear to prove. __________________ Here is another one for B6. Journal of Clinical Endocrinology & Metabolism, Vol 42, 1192-1195, Copyright © 1976 by Endocrine Society -------------------------------------------------------------------------------- ARTICLES Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6) EN McIntosh Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day). In each the galactorrhea ceased and serum prolactin levels were maintained in the normal range while taking pyridoxine. In two other women with prolonged secondary amenorrhea but without hyperprolactinemia or galactorrhea, pyridoxine at dosages up to 600 mg/day did not restore ovulatory menses. Pyridoxine treatment was also ineffective in decreasing profuse galactorrhea in one woman with normal prolactin levels and regular ovulatory menses. In the three women effectively treated with pyridoxine, the galactorrhea returned, serum prolactin levels increased, and the menses ceased after discontinuing pyridoxine. These results imply that pyridoxine, by decreasing the excessive secretion of prolactin, may be useful in the long-term medical management of women with hyperprolactinemia and the galactorrhea-amenorrhea syndrome. __________________ Here is one on Bromo. Journal of Clinical Endocrinology & Metabolism, Vol 42, 1024-1030, Copyright © 1976 by Endocrine Society -------------------------------------------------------------------------------- ARTICLES Prolactin and thyrotropin responses to thyrotropin-releasing hormone in patients with secondary amenorrhea: the effect of bromocriptine E Hirvonen, T Ranta and M Seppala Prolactin (PRL) and thyrotropin (TSH) responses to a 200 mug intravenous thyrotropin-releasing hormone (TRH) bolus were measured by radioimmunoassay in 11 women with hyperprolactinemic amenorrhea and 9 with normoprolactinemic amenorrhea. In all cases, the tests were carried out under basal conditions and repeated during bromocriptine treatment. In women whose basal PRL level was normal; TRH caused a maximal PRL increment of 85 +/- 25.2 mug/l (mean +/- SE), while those women whose basal PRL level was raised showed a smaller increase (5.2 +/- 11.9 mug/l) (P=0.02). The peak levels were not significantly different in these two groups (95.0 +/- 26.7 and 134.6 +/- 35.9 mug/l) (P is greater than 0.1). During bromocriptine treatment, the raised PRL levels decreased in all cases, but levels over 30 mug/l remained in 3 patients, one of whom turned out to have a pituitary tumor. Prolactin responses to TRH were markedly inhibited in normoprolactinemic patients by the dose of bromocriptine used. The mean maximal net increase of PRL was 2.0 +/- 0.9 mug/l in normoprolactinemic patients and 11.0 +/- 8.1 mug/l in hyperprolactinemic patients taking bromocriptine. After TRH stimulation during bromocriptine, the peak PRL levels in hyperprolactinemic patients were higher (32.7 +/- 10.5 mug/l) than in normoprolactinemic patients (7.2 +/- 1.5 mug/l). Unlike what has been described for hypothyroid patients, the basal TSH level in euthyroid amenorrhea patients was not affected by bromocriptine, and we found that bromocriptine has no effect on the TRH-TSH response. __________________
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14-08-2004, 06:05 PM
| #2 (permalink) |
| Super Moderator  Join Date: Jul 2003 Location: Sunny Southern California U.S.A.
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   | Nice, Wish i read this last year after a huge Deca only cycle. Thanks.
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14-08-2004, 07:47 PM
| #4 (permalink) |
| Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A.
Posts: 22,649
| Yah but the androgens raise my blood pressure through the roof. I am a little undecided if I am going to cycle again.
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15-08-2004, 04:34 PM
| #6 (permalink) |
| Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A.
Posts: 22,649
| If I could control my blood pressure I would be on a cycle right now. I liked the Deca alot but the shutdown is murder. Deca for me started kicking in really late like week 6 then pieked around week 12-13. Sex drive was ok during but afterwards. OMG zero. It was so bad after about 14 weeks i did a test cycle to help me out (and it did). I would like to do another cycle but be with Dr. care on monitering things. I love feeling like superman on a cycle but on the down side, what goes up must come down and I dont like the downside at all. I have the most massive post cycle recovery plan of anyone I have seen. Truely discusting the money I use for post cycle. I have everything but bio-rythem therapy. 
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15-08-2004, 06:49 PM
| #8 (permalink) |
| Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A.
Posts: 22,649
| It got up there at about 160/100 and stayed there night and day. This created problems with the kidneys (blood in urine). Not good had to cut my cycle right there. I think I do better health wise on the anabolics but the shutdown is worse. Catch 22, problem is I still have alot of gear and PCT stuff, tons of needles and everything. I think I will stick to the HGH. Much more mild but much more expensive. Another catch 22.
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