Bromocriptine Vs Cabergoline - UK-Muscle Body Building Community

Stu · 27-05-2005, 05:16 PM

Quote:

Originally Posted by http://www.biopsychiatry.com/cabergolinesex.htm

Cabergoline treatment rapidly improves gonadal function in hyperprolactinemic males: a comparison with bromocriptine
by
De Rosa M, Colao A, Di Sarno A, Ferone D,
Landi ML, Zarrilli S, Paesano L, Merola B, Lombardi G.
Department of Endocrinology and Molecular and Clinical Oncology,
Federico II University, Naples, Italy.
Eur J Endocrinol 1998 Mar;138(3):286-93

ABSTRACT

Quote:

Originally Posted by http://www.biopsychiatry.com/cabergolinesex.htm

This study evaluated the effects of chronic treatment with cabergoline (CAB), a new, potent and long-lasting ergoline-derived dopamine agonist, on seminal fluid parameters and sexual and gonadal function in hyperprolactinemic males in comparison with the effect of bromocriptine (BRC) treatment. Seventeen males with macroprolactinoma were treated with CAB at a dose of 0.5-1.5 mg/week (n = 7), or BRC at a dose of 5-15 mg/day (n = 10) for 6 months. Baseline prolactin (PRL) was 925.7 +/- 522.6 microg/l in the CAB-treated group and 1059.4 +/- 297.6 microg/l in the BRC-treated group. All the patients suffered from libido impairment, ten from reduced sexual potency, and six had infertility. In five patients provocative bilateral galactorrhea was found. Seminal fluid analysis, functional seminal tests and penis rigidity and tumescence, measured by nocturnal penile tumescence (NPT) using Rigiscan equipment, were assessed before and after 1, 3 and 6 months of CAB or BRC treatment. Hormone profiles were assessed before and after 15, 30, 60, 90 and 180 days of both treatments. Before treatment, all patients had a low sperm count with oligoasthenospermia, reduced motility and rapid progression with an abnormal morphology and decreased viability, and a low number of erections. After 1 month, serum PRL levels were significantly reduced in both groups of patients (20.6 +/- 6.6 microg/l during CAB and 256.3 +/- 115.1 microg/l during BRC treatment) and were normalized after 6 months in all patients (CAB: 7.9 +/- 2.2 microg/l; BRC: 16.7 +/- 1.8 microg/l). After 6 months, a significant increase of number, total motility, rapid progression and normal morphology was recorded in patients treated with both CAB and BRC. An increase in the number of erections during the first 3 months of both treatments was noted by NPT. However, the improvements in seminal fluid parameters and sexual function were more evident and rapid in patients treated with CAB. The number of erections was normalized after 6 months of treatment in all patients submitted to CAB treatment, and in all patients but one treated by BRC. In addition, a significant increase of serum testosterone (from 3.7 +/- 0.3 to 5.3 +/- 0.2 microg/l) and dihydrotestosterone (from 0.4 +/- 0.1 to 1.1 +/- 0.1 nmol/l) was recorded. At the beginning of treatment, mild side-effects were recorded in two patients after CAB and mild-to-moderate side-effects in five patients after BRC administration. The treatment with CAB normalized PRL levels, improving gonadal and sexual function and fertility in males with prolactinoma, earlier than did BRC treatment, providing good tolerability and excellent patient compliance to medical treatment.

MackenzieD · 24-09-2005, 09:58 AM

Hi guys,

I am a female bodybuilder. I'm getting back into shape since I stopped lifting. I plan to compete in Max Muscle Naturals in March.

I have a problem; I have raised prolactin levels. I tried bromocriptine for months. It made me tired and sick. I hate it! I want an alternative to get my prolactin down.

What effect does bromocriptine have on testosterone. In order for me to get big, I need test. What effect does Bromo have on GH, progesterine, and all the other hormones controlled by the pituitary gland.

I don't have a tumor in my pituitary gland. Does anyone know what could cause raised prolactin levels. The doctors are dumb asses and haven't been able to find out. I have just been going on without the bromo. Lack of medication has caused me to gain weight and the obvious.

Any suggestions on what I can do.

email your post to technoflute@hotmail.com

damagedgoods · 26-09-2005, 11:07 AM

Other than tumors - thyroid disease, polycystic ovary syndrome and shingles are also associated with modest degrees of hyperprolactinaemia... do you know what your prolactin level is? Also are you taking any other drucgs such as painkillers, anti-depressants or opiates??

**hackskii** · 29-09-2005, 02:04 AM

Ok, first of all Cabergoline is really Dostinex, also refered to as Cabaser.

From what I have read bromocriptine has many sides, most of them not good.

Dostinex, Is for hyperprolactinaemia.

Prolactin is a hormone when women are pregnant and the body is getting ready for lactation or getting ready for breast feeding.

Prolactin is very bad for sex drive for men and at the end of a sesson of sex prolactin in men is the highest after orgasim.

Progesterone is high during pregnancy and is the number one hormone for supressing insulin.
I like progesterone and I actually take this myself.
Great stuff.

With the exception of prolcatin men and women have the same hormones but in diffrent ratios.
Yes women have testosterone (but about 1/10th as men).
Men have estrogen (due to aromatisation of testosterone to estradiol) but just one of the three estrogens as women estradiol.

I dont know why you have prolactin issues, could possibly be you are pregnant, maybe are hypothyroid, tumor, who knows, without testing this is all guess work.

I am not sure what bromo has on test levels.
I know having prolcatin issues in men can have severe shutdown of the HPTA but in women there is other mechanics involved which are totally diffrent.

I am no Dr. but I can look into things that might help (food wise), in blocking prolactin.
Bromo has alot of sides and cabaser is well tollerated.
You can PM me if you want to find this cheap source or just look for alternatives.

Either way, you might need some medical testing to see the root of this perticular problem.

24-09-2005, 09:58 AM	#2 (permalink)
MackenzieD Newbie Trainer Join Date: Sep 2005 Posts: 1	bromocriptine Hi guys, I am a female bodybuilder. I'm getting back into shape since I stopped lifting. I plan to compete in Max Muscle Naturals in March. I have a problem; I have raised prolactin levels. I tried bromocriptine for months. It made me tired and sick. I hate it! I want an alternative to get my prolactin down. What effect does bromocriptine have on testosterone. In order for me to get big, I need test. What effect does Bromo have on GH, progesterine, and all the other hormones controlled by the pituitary gland. I don't have a tumor in my pituitary gland. Does anyone know what could cause raised prolactin levels. The doctors are dumb asses and haven't been able to find out. I have just been going on without the bromo. Lack of medication has caused me to gain weight and the obvious. Any suggestions on what I can do. email your post to technoflute@hotmail.com

29-09-2005, 02:04 AM	#4 (permalink)
hackskii Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 22,517	Ok, first of all Cabergoline is really Dostinex, also refered to as Cabaser. From what I have read bromocriptine has many sides, most of them not good. Dostinex, Is for hyperprolactinaemia. Prolactin is a hormone when women are pregnant and the body is getting ready for lactation or getting ready for breast feeding. Prolactin is very bad for sex drive for men and at the end of a sesson of sex prolactin in men is the highest after orgasim. Progesterone is high during pregnancy and is the number one hormone for supressing insulin. I like progesterone and I actually take this myself. Great stuff. With the exception of prolcatin men and women have the same hormones but in diffrent ratios. Yes women have testosterone (but about 1/10th as men). Men have estrogen (due to aromatisation of testosterone to estradiol) but just one of the three estrogens as women estradiol. I dont know why you have prolactin issues, could possibly be you are pregnant, maybe are hypothyroid, tumor, who knows, without testing this is all guess work. I am not sure what bromo has on test levels. I know having prolcatin issues in men can have severe shutdown of the HPTA but in women there is other mechanics involved which are totally diffrent. I am no Dr. but I can look into things that might help (food wise), in blocking prolactin. Bromo has alot of sides and cabaser is well tollerated. You can PM me if you want to find this cheap source or just look for alternatives. Either way, you might need some medical testing to see the root of this perticular problem. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

26-09-2005, 11:07 AM	#3 (permalink)
damagedgoods Looking Freaky Join Date: Oct 2003 Location: Wisbech Posts: 764	Other than tumors - thyroid disease, polycystic ovary syndrome and shingles are also associated with modest degrees of hyperprolactinaemia... do you know what your prolactin level is? Also are you taking any other drucgs such as painkillers, anti-depressants or opiates??