More IGF info - UK-Muscle Body Building Community

the_gre8t_1ne · 22-12-2005, 12:51 PM

I didn't kno where to post it, but here's a lil info i found on it, that some might find usefull.

WHAT IS LR3 IGF-1?

Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substation of an Arg(R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide.

ok.... now in plain english:

IGF1 stands for insulin like growth factor. It mimics insulin in the human body and also at the same time makes the muscles more sensitive to insulin’s effects. It is a growth factor and is the most potent one in the human body at that. IGF causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. This was thought to only be possible during puberty. IGF is much more potent at this effect than growth hormone is, in fact almost all of the effects you see from growth hormone come from the increased amount of IGF that your liver produces when the GH is destroyed. So it would be very easy to say that IGF is a much more potent and cheaper alternative to GH use, although GH is more effective for fat loss than IGF due to some other effects that it causes such as metabolism increase and the ability to effectively use more insulin, t3, and anabolic steroids.

Another advantage that IGF has over GH is that it has much more of an affinity to attach to muscle cells instead of bone and organ cells. Growth hormone has been know to cause a lot of organ enlargement and bone elongation since it attaches to all types of receptor cells. IGF is much more likely to go where we want it, our muscle cells. IGF-1 attaches to myogenic stem cells, which are only located in muscle and connective tissues. These myogenic stem cells are responsible for the production of myoblast cells, which in turn are responsible for the buildup and repair of connective tissues (ligaments, tendons, cartilage, and joints to a certain extent).

So from this you can see that IGF-1 is great for increasing the strength of tendons and also for helping to heal existing injuries while at the same time helping to prevent them. IGF-1 is also responsible for increased protein synthesis and amino acid synthesis.

IGF does not have to be used along with anabolic steroids, GH, insulin, or thyroid hormones to be effective. It causes muscle growth on its own. In fact some people prefer to use it during their breaks from steroid cycles since IGF has no effect on natural test production. It could effectively be used along with HCG, Clomid, and PGF2a for a hell of an off cycle stack which would allow your body to return to normal and still allow you to grow!! On its own IGF will give an increase of around 2 lbs. of new solid lean muscle tissue every two weeks, and is also is know for its ability to strip off body fat and GREATLY increase vascularity, body fat decreases of 5-8% over a 50 day cycle are not uncommon. But, of course you will be much happier with the results if you use the IGF along with anabolic steroids, testosterone, and insulin.

The use of steroids along with the IGF allow you to quickly mature and strengthen the new muscle tissue that the IGF has formed, and may also speed the process of hyperplasia. If you need any help setting up a great stack to
use along with the IGF just let me know and I can help you out. I speak with lots of top bodybuilders and guru’s so I am very knowledgeable.

Also I should let you know that the form of IGF is the Long R3 analog. It has been chemically altered and has a longer half-life than regular IGF, which only lasts about 10 minutes in the human body once injected. The Long R3 IGF-1 has a half-life of 6-10 hours, so you will only need to inject once or twice per day. The best time to inject is after lifting and in the morning, so it would be best to use half the dosage in the morning and the other half after lifting. This will take maximal advantage of IGF’s insulin mimicking effects.

[left]

USAGE OF IGF-1 LR3

Everyone is different, so finding the right dose is a matter of trial and error. Some respond very well to low doses while others need more to acheive ultimate results.

As a starting point, we suggest 80mcgs-100mcg per day to determine how you respond. Most will find 100mcg to be a very effective dose. We have yet to see a major difference between 100mcg a day and 200mcg a day so injecting more than 100mcg a day is probably just wasting your IGF.

Each one of our kits comes in a 2ml vial containing 1000mcg of LR3 IGF-1.

Injections are administered twice per day at 40mcg-50mcg per injection. Most users will inject first thing upon waking up in the morning, and a second injection 45 minutes prior to workouts. IGF-1 injections are intra-muscular (so it must be injected into a muscle). Injections are totally painless as an insulin needle is very thin. You wont feel much more than a light pinch through the skin.

After each injection, its advised to eat a sufficient amount of protein and carbohydrates. 30g protein, 50g carbs should do the trick..

You always want to use an inslin syringe when using IGF. Measuring igf on any insulin syringe is simple. Each 1i.u is10mcg. It may seem like a very small amount but dont let it decieve you.... this IGF-1 is super strong!

Once the desired dose is in the syringe, it is optional to add Bacteriostatic Water. Some report that adding the water eases the slight sting following the injecting but we do not feel it necessary.

[left]

WHAT TO EXPECT FROM LR3 IGF-1

Typical gains from our IGF are 1-2 pounds of lean muscle mass per week, although some have reported up to 5 pounds the10 days. It really comes down to genetics. Most noticeable will be the amazing pumps, and the 'veiny' shredded look which generally lasts all day.
Some users reported a steady decrease in fat. This is because IGF increases muscle mass, so IGF can also be used to get lean, although its best use is to build alot of muscle FAST!
IGF is best taken for a minimum of 4 weeks and up to 6 weeks before taking a one month break.
Most users have reported amazing results with the 6 week on / 4 week off routine.

[font=Arial]IGF-1 has not yet been approved by the FDA for human consumption. IGF-1 is intended for research purposes only!

the_gre8t_1ne · 22-12-2005, 12:51 PM

But I would get mine prb from muscle research...

**Pscarb** · 22-12-2005, 01:14 PM

Sorry mate i have edited your post as this would be free advertising for this company.
Muscle Research pay for advertising so it would be unfair to them.

I and many other have purchased from MR with great success.

Great info by the way but i would caution on the use of 80-100mcg on your first go with IGF-1LR3 50mcg is sufficient.

the_gre8t_1ne · 22-12-2005, 01:21 PM

Quote:

Originally Posted by Pscarb

Sorry mate i have edited your post as this would be free advertising for this company.
Muscle Research pay for advertising so it would be unfair to them.

I and many other have purchased from MR with great success.

Great info by the way but i would caution on the use of 80-100mcg on your first go with IGF-1LR3 50mcg is sufficient.

yeah sorry about that, i tried to edit as much out of it, i missed out a few bits, i thaught it was easy info to understand by the way it was written.

**Aftershock** · 22-12-2005, 01:41 PM

I'll be getting the 100mcg bottles of IGF, and reconstituting with BAC water, if I use 50mcg a day will the other 50mcg keep till the following day or do I need to get the special solvent?

**Pscarb** · 22-12-2005, 02:09 PM

yes mate it will keep for 24-36hrs..

**Aftershock** · 22-12-2005, 04:44 PM

Given the fact that IGF acts in a similar maner to slin why is it that we associate slin use with gaining some bodyfat and IGF with leaning out?

**Pscarb** · 22-12-2005, 06:07 PM

IGF is called Insulin Like Growth Factor it does not mimick insulin in everyway

**hackskii** · 02-04-2006, 08:13 PM

I dont think you are supposed to use bac water.
AA is used to make it the right PH or something so you can use it.

I hear bac water breaks it down.

I am using 40mcg and in the beginning I was using 80mcg by accident and boy oh freaking boy does it make the ol vains stand out big time.
Also in the beginning with the 80mcg I was dieting and noticed I really wasnt losing much weight compared to me backing it off.
Never thought of the 2lb a week muscle gain tho

Might be the reason I wasnt losing weight.

I do like it though.

**Pscarb** · 02-04-2006, 08:32 PM

you can use BA water, this was the solution sold with the original from groprep and Gensci although AA water extends the shelf life considerably..

John · 02-04-2006, 08:44 PM

im struggling with daily doses and how much is in the bottle etc, ive read lots in here and in books and ive looked at the site ( mr ), but i still require some help.

Say the bottle has 1mg / ml, how much is in that?

If were talking about 50mcg pd for the 4 weeks, how much will be required ?

I know this is a really basic q, but ive got my head round everything but this.

Ari · 02-04-2006, 08:50 PM

this is a post by paul

Hello mate

I am using the pre-mixed at the moment.

It comes in a vial of 1ml/1mg.

This means there is 1000mcgs per vial.

You inject it using Insulin pins, so if you have a 1ml slin pin (100iu) and wanted to run 80mcgs ED you would do 2 shots of 4iu each (one am, one pm PWO)

Its quite hard to measure, im prolly doing more like 90 - 100mcgs due to trying to measure it.

Thanks

Paul

John · 02-04-2006, 09:00 PM

all is now clear, i suppose i should just have asked how many mcgs in the bottle, or if id used any of the sense i think i have id have figured this out.

break · 03-04-2006, 01:12 AM

good post! ive never read anything on this befor i take this stuff is for the more experienced? just sounds good that u can run this from start to finish of cycle including pct...

john can i ask are u runnin this on its own or stacked?

and if u have ever done it before what sides you experienced?

cheers

BIG-UNC · 03-04-2006, 05:50 AM

good post even i could understand it!!!!!!!...unc

but why only the short cycles of 4-6 weeks as it states this stuff doesnt

mess with our own test levels then why couldnt it be run for longer?

and why the 4 week break couldnt understant this bit!

22-12-2005, 12:51 PM	#1 (permalink)
the_gre8t_1ne Your Friendly neighbourhood pusha! Join Date: Apr 2005 Location: The Ghetto (West, London) Posts: 4,027	More IGF info I didn't kno where to post it, but here's a lil info i found on it, that some might find usefull. WHAT IS LR3 IGF-1? Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substation of an Arg(R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide. ok.... now in plain english: IGF1 stands for insulin like growth factor. It mimics insulin in the human body and also at the same time makes the muscles more sensitive to insulin’s effects. It is a growth factor and is the most potent one in the human body at that. IGF causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. This was thought to only be possible during puberty. IGF is much more potent at this effect than growth hormone is, in fact almost all of the effects you see from growth hormone come from the increased amount of IGF that your liver produces when the GH is destroyed. So it would be very easy to say that IGF is a much more potent and cheaper alternative to GH use, although GH is more effective for fat loss than IGF due to some other effects that it causes such as metabolism increase and the ability to effectively use more insulin, t3, and anabolic steroids. Another advantage that IGF has over GH is that it has much more of an affinity to attach to muscle cells instead of bone and organ cells. Growth hormone has been know to cause a lot of organ enlargement and bone elongation since it attaches to all types of receptor cells. IGF is much more likely to go where we want it, our muscle cells. IGF-1 attaches to myogenic stem cells, which are only located in muscle and connective tissues. These myogenic stem cells are responsible for the production of myoblast cells, which in turn are responsible for the buildup and repair of connective tissues (ligaments, tendons, cartilage, and joints to a certain extent). So from this you can see that IGF-1 is great for increasing the strength of tendons and also for helping to heal existing injuries while at the same time helping to prevent them. IGF-1 is also responsible for increased protein synthesis and amino acid synthesis. IGF does not have to be used along with anabolic steroids, GH, insulin, or thyroid hormones to be effective. It causes muscle growth on its own. In fact some people prefer to use it during their breaks from steroid cycles since IGF has no effect on natural test production. It could effectively be used along with HCG, Clomid, and PGF2a for a hell of an off cycle stack which would allow your body to return to normal and still allow you to grow!! On its own IGF will give an increase of around 2 lbs. of new solid lean muscle tissue every two weeks, and is also is know for its ability to strip off body fat and GREATLY increase vascularity, body fat decreases of 5-8% over a 50 day cycle are not uncommon. But, of course you will be much happier with the results if you use the IGF along with anabolic steroids, testosterone, and insulin. The use of steroids along with the IGF allow you to quickly mature and strengthen the new muscle tissue that the IGF has formed, and may also speed the process of hyperplasia. If you need any help setting up a great stack to use along with the IGF just let me know and I can help you out. I speak with lots of top bodybuilders and guru’s so I am very knowledgeable. Also I should let you know that the form of IGF is the Long R3 analog. It has been chemically altered and has a longer half-life than regular IGF, which only lasts about 10 minutes in the human body once injected. The Long R3 IGF-1 has a half-life of 6-10 hours, so you will only need to inject once or twice per day. The best time to inject is after lifting and in the morning, so it would be best to use half the dosage in the morning and the other half after lifting. This will take maximal advantage of IGF’s insulin mimicking effects. [left] USAGE OF IGF-1 LR3 Everyone is different, so finding the right dose is a matter of trial and error. Some respond very well to low doses while others need more to acheive ultimate results. As a starting point, we suggest 80mcgs-100mcg per day to determine how you respond. Most will find 100mcg to be a very effective dose. We have yet to see a major difference between 100mcg a day and 200mcg a day so injecting more than 100mcg a day is probably just wasting your IGF. Each one of our kits comes in a 2ml vial containing 1000mcg of LR3 IGF-1. Injections are administered twice per day at 40mcg-50mcg per injection. Most users will inject first thing upon waking up in the morning, and a second injection 45 minutes prior to workouts. IGF-1 injections are intra-muscular (so it must be injected into a muscle). Injections are totally painless as an insulin needle is very thin. You wont feel much more than a light pinch through the skin. After each injection, its advised to eat a sufficient amount of protein and carbohydrates. 30g protein, 50g carbs should do the trick.. You always want to use an inslin syringe when using IGF. Measuring igf on any insulin syringe is simple. Each 1i.u is10mcg. It may seem like a very small amount but dont let it decieve you.... this IGF-1 is super strong! Once the desired dose is in the syringe, it is optional to add Bacteriostatic Water. Some report that adding the water eases the slight sting following the injecting but we do not feel it necessary. [left] WHAT TO EXPECT FROM LR3 IGF-1 Typical gains from our IGF are 1-2 pounds of lean muscle mass per week, although some have reported up to 5 pounds the10 days. It really comes down to genetics. Most noticeable will be the amazing pumps, and the 'veiny' shredded look which generally lasts all day. Some users reported a steady decrease in fat. This is because IGF increases muscle mass, so IGF can also be used to get lean, although its best use is to build alot of muscle FAST! IGF is best taken for a minimum of 4 weeks and up to 6 weeks before taking a one month break. Most users have reported amazing results with the 6 week on / 4 week off routine. [font=Arial]*IGF-1 has not yet been approved by the FDA for human consumption.* *IGF-1 is intended for research purposes only!* __________________ Know your role and shut your mouth! or I'll layeth the SMACK DOWN on your Candy ASS!! If you smelalalalalalooouuuu To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. the gre8t 1ne.......is cooking!? To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. also find me at To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Last edited by Pscarb; 22-12-2005 at 01:11 PM.

22-12-2005, 12:51 PM	#2 (permalink)
the_gre8t_1ne Your Friendly neighbourhood pusha! Join Date: Apr 2005 Location: The Ghetto (West, London) Posts: 4,027	But I would get mine prb from muscle research... __________________ Know your role and shut your mouth! or I'll layeth the SMACK DOWN on your Candy ASS!! If you smelalalalalalooouuuu To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. the gre8t 1ne.......is cooking!? To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. also find me at To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

22-12-2005, 01:14 PM	#3 (permalink)
Pscarb UK-Muscle Moderator and NABBA Champion Join Date: Jan 2005 Posts: 10,183	Sorry mate i have edited your post as this would be free advertising for this company. Muscle Research pay for advertising so it would be unfair to them. I and many other have purchased from MR with great success. Great info by the way but i would caution on the use of 80-100mcg on your first go with IGF-1LR3 50mcg is sufficient. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Admin at To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Nutrition is your greatest anabolic agent everything else is just the icing on the cake

22-12-2005, 01:41 PM	#5 (permalink)
Aftershock UK-Muscle Moderator Join Date: Jan 2004 Posts: 3,931	I'll be getting the 100mcg bottles of IGF, and reconstituting with BAC water, if I use 50mcg a day will the other 50mcg keep till the following day or do I need to get the special solvent? __________________ "You are what you eat you can't possibly be anything else" or put another way "eat sht look like sht!!" Aftershock Last edited by Aftershock; 22-12-2005 at 01:43 PM.

22-12-2005, 02:09 PM	#6 (permalink)
Pscarb UK-Muscle Moderator and NABBA Champion Join Date: Jan 2005 Posts: 10,183	yes mate it will keep for 24-36hrs.. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Admin at To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Nutrition is your greatest anabolic agent everything else is just the icing on the cake

22-12-2005, 04:44 PM	#7 (permalink)
Aftershock UK-Muscle Moderator Join Date: Jan 2004 Posts: 3,931	Given the fact that IGF acts in a similar maner to slin why is it that we associate slin use with gaining some bodyfat and IGF with leaning out? __________________ "You are what you eat you can't possibly be anything else" or put another way "eat sht look like sht!!" Aftershock

22-12-2005, 06:07 PM	#8 (permalink)
Pscarb UK-Muscle Moderator and NABBA Champion Join Date: Jan 2005 Posts: 10,183	IGF is called Insulin Like Growth Factor it does not mimick insulin in everyway __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Admin at To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Nutrition is your greatest anabolic agent everything else is just the icing on the cake

02-04-2006, 08:13 PM	#9 (permalink)
hackskii UK-Muscle Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 23,164	I dont think you are supposed to use bac water. AA is used to make it the right PH or something so you can use it. I hear bac water breaks it down. I am using 40mcg and in the beginning I was using 80mcg by accident and boy oh freaking boy does it make the ol vains stand out big time. Also in the beginning with the 80mcg I was dieting and noticed I really wasnt losing much weight compared to me backing it off. Never thought of the 2lb a week muscle gain tho Might be the reason I wasnt losing weight. I do like it though. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

02-04-2006, 08:32 PM	#10 (permalink)
Pscarb UK-Muscle Moderator and NABBA Champion Join Date: Jan 2005 Posts: 10,183	you can use BA water, this was the solution sold with the original from groprep and Gensci although AA water extends the shelf life considerably.. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Admin at To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. Nutrition is your greatest anabolic agent everything else is just the icing on the cake

02-04-2006, 08:44 PM	#11 (permalink)
John EFBB Winner Join Date: Jun 2004 Posts: 4,245	i know its probably been asked before but im struggling with daily doses and how much is in the bottle etc, ive read lots in here and in books and ive looked at the site ( mr ), but i still require some help. Say the bottle has 1mg / ml, how much is in that? If were talking about 50mcg pd for the 4 weeks, how much will be required ? I know this is a really basic q, but ive got my head round everything but this. __________________ *“We can't solve problems by using the same kind of thinking we used when we created them.”*

02-04-2006, 08:50 PM	#12 (permalink)
Ari Gym Instructor Join Date: Sep 2005 Posts: 82	this is a post by paul Hello mate I am using the pre-mixed at the moment. It comes in a vial of 1ml/1mg. This means there is 1000mcgs per vial. You inject it using Insulin pins, so if you have a 1ml slin pin (100iu) and wanted to run 80mcgs ED you would do 2 shots of 4iu each (one am, one pm PWO) Its quite hard to measure, im prolly doing more like 90 - 100mcgs due to trying to measure it. Thanks Paul

02-04-2006, 09:00 PM	#13 (permalink)
John EFBB Winner Join Date: Jun 2004 Posts: 4,245	cheers all is now clear, i suppose i should just have asked how many mcgs in the bottle, or if id used any of the sense i think i have id have figured this out. __________________ *“We can't solve problems by using the same kind of thinking we used when we created them.”*

03-04-2006, 01:12 AM	#14 (permalink)
break Gym Addict Join Date: Oct 2005 Location: south east Posts: 133	good post! ive never read anything on this befor i take this stuff is for the more experienced? just sounds good that u can run this from start to finish of cycle including pct... john can i ask are u runnin this on its own or stacked? and if u have ever done it before what sides you experienced? cheers __________________ you grow in the kitchen then in the gym

03-04-2006, 05:50 AM	#15 (permalink)
BIG-UNC IF YOU BUILD IT.....THEY WILL COME! Join Date: Feb 2006 Location: middlesbrough Posts: 1,945	good post even i could understand it!!!!!!!...unc but why only the short cycles of 4-6 weeks as it states this stuff doesnt mess with our own test levels then why couldnt it be run for longer? and why the 4 week break couldnt understant this bit!

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