Why do guys get sterile during a cycle? - UK-Muscle Body Building Community

**hackskii** · 30-09-2005, 06:21 PM

Why do anabolic androgenic steroids cause a person to be sterile
during a cycle?

The hypothalamus releases a substance called gonadotropin releasing
hormone (GnRH), which is carried to the nearby pituitary gland.
The arrival of GnRH in the pituitary serves as a signal to release
two hormones luteinizing hormone (LH) and follicle stimulating hormone
(FSH) into general circulation.

When LH reaches the Leydig cells of the testes, it basically tells
the testicles to make testosterone which goes into the blood stream.

The production of sperm in the testes is closely tied to this
hormonal cycle.
FSH released from the pituitary binds to specific receptors
in another part of the testes called the Sertoli cells, which are
located in the seminiferous tubles, the structure that comprises about
80 to 90% of the mass in the testicles. By stimulating the production
of protein that binds androgens, FSH promotes a higher concentration
of testosterone in this region, which stimulates the maturation of
sperm cells (spermatogenesis). Each day from puberty to death, the
testes produce about 30 million new sperm.

When one adds exogenous (external) testosterone, the body through a
complex hormonal system, regulates itself via a negative feedback
loop.

When excess estradiol and to some extent DHT reach the hypothalamus
they inhibit the release of GnRH initiating the classic negative
feedback loop.
I am sure that the body realizes that there is too much testosterone
too and I am sure this is part of the negative feed back and even
suspect blocking DHT and estrogen there would still be some shutdown.

So LH and FSH won't make it to their target cells (Leydig and Sertoli
cells) to the response is testicular atrophy.

What I think is interesting is I get massive testicular atrophy and
thought this was from the nuts not producing testosterone, and this
may be true but if 80 to 90% of the mass in the testicles are Sertoli
cells and stimulated by FSH (which is the mechanism for sperm
production) then actually it is the shutdown of sperm I am guessing that is
what I am noticing (size diffrence).

So if the nuts don't produce testosterone due to shutdown of LH and
the pituitary gland does not send out FSH due to shutdown there is no
testosterone in the testicles to produce any sperm.

This is why I think guys on gear are temporarily sterile.

**hackskii** · 11-12-2005, 06:33 PM

Melatonin has some effect on FSH but I am not sure if it is for the better or worse....Sorry...

You suffer from low sperm count too?

**Aftershock** · 12-12-2005, 09:40 AM

Quote:

Originally Posted by hackskii

Melatonin has some effect on FSH but I am not sure if it is for the better or worse....Sorry...

You suffer from low sperm count too?

HCG keeps the nuts producing test right and we know it prevents atrophy, so can we also conclude that it would have a positive effect on sperm levels?

RAIKEY · 12-12-2005, 10:07 AM

slightly OT guys but still interesting....

my father in law had cancer of the larynx and as such has just had surgery(last monday) to remove it...which leaves him with a stoma ( a hole in his neck thru which to breathe).....

now i heard the family also saying that he had his pitruatary gland removed too as a precaution...?

i'm not sure the family member got it right did they??

can a person function without this?

is it in the neck area in the first place??

i'm guessing if its true, he'll have to have a constant intake of suppliments,??

isnt this gland responsible for production of a whole host of other substances?..

the doc's are already giving him calcium and magnesium, will he need some sort of hormone therapy too?

its a bit of a touchy subject at the moment so i dont wanna ask the family or doctors ....but i would like to be a little more prepared for when he comes home....

a lot of questions guys i know,(sorry) but it was Hackskii's post bout this that got me wondering.

**hackskii** · 12-12-2005, 01:39 PM

The thyroid is in the neck, pituitary gland is in the brain.
Without the thyroid, you will just have to supplement some T3 and T4, not a problem there.

Aftershock, I think Pharma just ment his levels of FSH were low and was wondering what would be good to take or eat to raise FSH.

RAIKEY · 12-12-2005, 01:46 PM

Quote:

Originally Posted by hackskii

The thyroid is in the neck, pituitary gland is in the brain.
Without the thyroid, you will just have to supplement some T3 and T4, not a problem there.

Doh!

how dumb do i sound?

Thyroid that was the one !!

fcuking pitruatry gland !!!??...what was i thinking...

if you look at the time i posted you'll see it was a bit early....

sorry for the hijack folks !....back to you!

**Aftershock** · 14-12-2005, 09:31 AM

Quote:

Originally Posted by hackskii

Aftershock, I think Pharma just ment his levels of FSH were low and was wondering what would be good to take or eat to raise FSH.

Yes but if HCG stops testicular atrophy (you said that 80 to 90% of the mass in the testicles are Sertoli cells) and stimulates thest production in the nuts can we also conclute that it will help with sperm production?

**hackskii** · 14-12-2005, 05:19 PM

Quote:

Originally Posted by Aftershock

Yes but if HCG stops testicular atrophy (you said that 80 to 90% of the mass in the testicles are Sertoli cells) and stimulates thest production in the nuts can we also conclute that it will help with sperm production?

Sperm production comes from FSH.
HCG mimmics LH.

"By stimulating the production
of protein that binds androgens, FSH promotes a higher concentration
of testosterone in this region, which stimulates the maturation of
sperm cells (spermatogenesis)."

I dont know if HCG elevates FSH or not but I kindof think for some reason it does.
If the nuts get atrophied and you lose alot of size in there it would make sense considering the sertoli cells make up the majority of the mass of the testicles.
If the leydig cells only make up a small portion then why such size diffrence?
This is why I think HCG might raise FSH or maybe allow for more testosterone production in the nuts to produce sperm.

Not sure but the article I copied it from didnt say.
Maybe I can look into this and have an answer.

30-09-2005, 06:21 PM	#1 (permalink)
hackskii Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 22,669	Why do guys get sterile during a cycle? Why do anabolic androgenic steroids cause a person to be sterile during a cycle? The hypothalamus releases a substance called gonadotropin releasing hormone (GnRH), which is carried to the nearby pituitary gland. The arrival of GnRH in the pituitary serves as a signal to release two hormones luteinizing hormone (LH) and follicle stimulating hormone (FSH) into general circulation. When LH reaches the Leydig cells of the testes, it basically tells the testicles to make testosterone which goes into the blood stream. The production of sperm in the testes is closely tied to this hormonal cycle. FSH released from the pituitary binds to specific receptors in another part of the testes called the Sertoli cells, which are located in the seminiferous tubles, the structure that comprises about 80 to 90% of the mass in the testicles. By stimulating the production of protein that binds androgens, FSH promotes a higher concentration of testosterone in this region, which stimulates the maturation of sperm cells (spermatogenesis). Each day from puberty to death, the testes produce about 30 million new sperm. When one adds exogenous (external) testosterone, the body through a complex hormonal system, regulates itself via a negative feedback loop. When excess estradiol and to some extent DHT reach the hypothalamus they inhibit the release of GnRH initiating the classic negative feedback loop. I am sure that the body realizes that there is too much testosterone too and I am sure this is part of the negative feed back and even suspect blocking DHT and estrogen there would still be some shutdown. So LH and FSH won't make it to their target cells (Leydig and Sertoli cells) to the response is testicular atrophy. What I think is interesting is I get massive testicular atrophy and thought this was from the nuts not producing testosterone, and this may be true but if 80 to 90% of the mass in the testicles are Sertoli cells and stimulated by FSH (which is the mechanism for sperm production) then actually it is the shutdown of sperm I am guessing that is what I am noticing (size diffrence). So if the nuts don't produce testosterone due to shutdown of LH and the pituitary gland does not send out FSH due to shutdown there is no testosterone in the testicles to produce any sperm. This is why I think guys on gear are temporarily sterile. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

11-12-2005, 06:33 PM	#2 (permalink)
hackskii Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 22,669	Melatonin has some effect on FSH but I am not sure if it is for the better or worse....Sorry... You suffer from low sperm count too? __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

12-12-2005, 10:07 AM	#4 (permalink)
RAIKEY Please do not feed the Raikey, it may bite.!! Join Date: Jun 2005 Location: Deepest, Darkest , Yorkcestershire,...Ayup See thee!! Posts: 3,379	slightly OT guys but still interesting.... my father in law had cancer of the larynx and as such has just had surgery(last monday) to remove it...which leaves him with a stoma ( a hole in his neck thru which to breathe)..... now i heard the family also saying that he had his pitruatary gland removed too as a precaution...? i'm not sure the family member got it right did they?? can a person function without this? is it in the neck area in the first place?? i'm guessing if its true, he'll have to have a constant intake of suppliments,?? isnt this gland responsible for production of a whole host of other substances?.. the doc's are already giving him calcium and magnesium, will he need some sort of hormone therapy too? its a bit of a touchy subject at the moment so i dont wanna ask the family or doctors ....but i would like to be a little more prepared for when he comes home.... a lot of questions guys i know,(sorry) but it was Hackskii's post bout this that got me wondering. __________________ I used to have a large gay following.......but i hid behind some cars and lost him!!

12-12-2005, 01:39 PM	#5 (permalink)
hackskii Super Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 22,669	The thyroid is in the neck, pituitary gland is in the brain. Without the thyroid, you will just have to supplement some T3 and T4, not a problem there. Aftershock, I think Pharma just ment his levels of FSH were low and was wondering what would be good to take or eat to raise FSH. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

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