Ironman

What is this exactly and is it worth taking along with gear?

Kel

Pulled this off elite a while back but havent read it may help you

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KEL
Better to have tried and failed than never to have tried at all!

Kel

well it would if i could put the fecking attachment on give me a min

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KEL
Better to have tried and failed than never to have tried at all!

Kel

ant find anyway of attaching the document ive tried the advanced option and still no joy if you let me know how to do it i will post it up for you or if you pm me your email i will send it that way.

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KEL
Better to have tried and failed than never to have tried at all!

Pscarb

IGF 1 info

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Found this on another board should help you out a bit.


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I feel like I ought to offer some more thoughts, with respect to IGF-1.

I begin by saying that I've used the stuff on myself, under several different regimens. But, more importantly, I've now worked with quite a number of other athletes, using IGF-1. In these situations, I've had control over the dosage, administration, and diet. And I've prepared the IGF-1 injectable under standardized conditions, using appropriate buffers. I would receive regular reports and observations from the users. While I do not consider my data to have a sample size which would stand a test of statistical validity, my data base is larger and better quality than the individual anecdotal observations seen in board threads.

There are a tremendous number of issues, not directly related to IGF response, and I'll discuss them, first.

There are a number of boards which are seen as authorities for good information, yet are polluted by members and mods who are directly connected with IGF dealers. Furthermore, there are buyers who have been induced to act as shills. These people never identify their roles, and they have completely muddied the waters with their hype and outright lies. For example, I know of one guy who is an IGF powder middleman, and he has managed to get himself known as an IGF "expert", even though he has absolutely no science background. He goes around from board to board belching out some of the most absurd hype I've ever seen, all the while hustling people to buy their IGF from the company he sells his powder to.

Then there are the ones who have some decent knowledge, but have gotten their knowledge all mixed up. In that thread cited, above, from the Cutting Edge Muscle board, one member posts about how good he thinks IGF is, then he offers a proposed ideal diet for maximizing the effect of IGF. Well, if you look at that diet, you will realize that you can do that diet, and put on 5-6 pounds easy, and not use any IGF-1! It's the diet that is making you grow, not the IGF!! Just ridiculous!!! Anyone should be able to see through that sort of nonsense, yet IGF is seen as such a "Holy Grail", that things like this are overlooked.

Another class of post is by those who don't fully understand what is happening, when they use IGF-1. Yes, some legit research has shown that IGF can multiply muscle fiber. But it is clear to me that the bulk of the response to IGF comes from it's ability to act as a sensational glucose disposal agent. This is the part where IGF's name, "Insulinlike", comes to the fore. IGF can send you into ketosis with ease. Good responders to IGF are hungry all the time, because the blood glucose is held low. All that glycogen is being driven into the muscles. The frequent reports of muscle fullness and vascularity is the result of muscles being pumped full of glycogen and water.

There is too little mention of the non-responders to IGF-1. They definitely exist. But identifying the percentage of them in the population is difficult, due to the way most IGF is being sold. I'll discuss that, next.

The business is rife with misinformation on how to properly prepare the IGF-1 for use. The ONLY proper way to rehydrate IGF-1 for use, where it will be at full strength and activity, is with an aqueous buffer solution, which has the proper pH and ionic(salt) content. However, it is not easy or safe for the average user to prepare such a buffer, and access to the raw materials is limited.

A couple of years ago, Animal concocted the idea of dissolving the IGF he was selling, in some BA. He perhaps did not have access to the proper buffer materials, and he came up with this idea, in order to promote his business. Well, it sort of worked. But some, if not most, of the IGF is rendered useless by this method, since you need the correct pH and ionic environment for the peptide chains to unwind. In the end, you have to use a lot of IGF, just to get the effect which you would get, if you had properly rehydrated it with a buffer. In my work, using a proper buffer, the maximum dosage per day is 30 mcg. But I've seen good results on only 15 to 20 mcg's per day. It is typical for users with the Animal type product to have to use 50 to 120 mcg per day, to see any effect at all.

Still another absurd notion is that you do not have to refridgerate the IGF in BA. I have seen some idiot "experts" recommend that "IGF-1 works better if you store it in your sock drawer".

Now, I'm a chemist, and I've worked in biochem labs, and seeing all this online nonsense about preparing IGF really makes me crazy. But, let's use a little common sense. Both IGF-1 and hGH are chain sequenced peptides. So, they are in the same family. Now, we all know that you rehydrate GH with an aqueous solution and we must store it under refridgeration. Yet, these "experts" say we can reconstitute IGF-1 with BA and it does not require any refridgeration. I ask you, have any of you ever seen anyone recommend that we reconstitute GH with BA, and that we not store it under refridgeration? I certainly never have. It seems to me that this would be a real breakthrough, right? Not a single legit biochemist has ever advocated the BA method for preparing chain sequenced peptides. Again, I have never seen one of these online "experts" advocate using BA for preparing GH, yet GH and IGF-1 are in the same family. Now, doesn't that tell you something??

So, you may begin with some active IGF in these BA preparations, but you end up with less and less, as it degrades.

Then there is the shipping. Ever wonder why we don't buy hGH in reconstituted form? Aside from having to keep it cold, all the shaking and agitation, which goes on in shipping and transportation, would destroy the peptide chains. Yet these "experts" say there's no problem in selling and transporting IGF-1 in liquid form. Are we to believe that BA creates some wondrous, new, indestructable environment for peptide chains?

So, now we go a step further. We begin with some active IGF in the BA preparation, but it degrades, and then we ship it, and then we lose still more and more.

By the time you end up with it, in your hands, there is little or no active IGF-1. So, now, how do we determine who is a IGF non-responder, and who simply has gotten a ruined bottle of IGF-1? How do we determine the full range of response in the population, when the IGF-1 in the field is of random strength and unknown concentration?

All these problems make a complete assessment of the true worth of IGF-1 very difficult. The buyer thinks he has 1000 mcg per ml of IGF-1, when, in reality, he has much less, maybe even none.

It is my contention that much of the weight gain, seen by IGF-1 users, is water. Their muscles appear to be growing, but it is glycogen and water. Some will respond in extreme. I had one user put on almost 15 pounds. All water! Three days after his IGF cycle ended, the water was gone, and so was the weight gain. So, we are mostly seeing bloat, to a greater or lessor degree, rather than spectacular muscle growth. This accounts for all the stories of giant pumps, while training on IGF-1.

I'm not convinced that there is really significant muscle growth. But I am convinced that there is bodyfat loss. As I mentioned, if your carbs are low enough, IGF-1 will get you into ketosis quickly, and then bodyfat loss will proceed accordingly.

IGF-1 is not useless. IGF-1 is, at present, a very specialized tool. I think it's best use comes with bulking. Through its very powerful glucose disposal effect, a responder is always hungry, and the nutrition is pumped into the muscles. People who have difficulty eating while bulking, may find that they have fewer problems packing in that food. But, if you're an ectomorph, that will result in a much greater food demand, since you will need to eat more to compensate for the loss in blood glucose. You will most certainly have to eat in the middle of the night, due to hunger.

IGF-1 is also useful while cutting, but it really makes you crave carbs, and, if you're not interested in going keto, then you end up having to eat more carbs than you would, otherwise. The glycogen pumping effect is anti catabolic, however.

But that's about it, as far as I'm concerned.

If you are to make the best use of IGF-1, then the preparation of the buffer will be a serious handicap. The starting materials are not easy to obtain, and the handling and storage of these chemicals is dangerous and difficult. If you prepare the buffer with the wrong pH, then you will completely destroy the IGF-1, the moment you add it to the buffer. You better know what you are doing, and have the correct equipment with which to do it.

There are so many more cost effective and productive ways to spend your money on muscle building, than with IGF-1. If you're adventurous, done plenty of research, and have a wad of cash, then go ahead and give it a try. But IGF-1 is not the Holy Grail of bodybuilding.

Have fun!
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AE Board Moderator and Admin.

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Ironman

Think I'll be giving that a miss then!!

Pscarb

Here is some one else's veiw on IGF-LR3

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Good IGF/R3IGF read
by BassKiller
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I believe :IntensityX


IGF stands for insulin-like growth factor. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body; I will only mention the points that would be important for physical enhancement. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

IGF also mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don't actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

There is a lot of talk about the similarity between IGF and growth hormone. The most often asked question is simply which is more effective. GH doesn't directly cause your muscles to grow, it works very indirectly by increasing protein synthesis capabilities, increasing the amount of insulin a person can use effectively, and increasing the amount of anabolic steroids a person can use effectively. GH also indirectly causes muscle growth by stimulating the release of IGF when it (the GH) is destroyed in the human body. So one way you could look at it as GH being a precursor to IGF. So to put it simple IGF is more effective at directly causing muscle growth and density increases. IGF is also much more cost effective.

IGF can also be effectively used by itself and gains will still be easily noticeable. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF. IGF can be used by itself and is often used by bodybuilders who bridge between cycles, during this bridge is a good time to use IGF since it has no effect on natural testosterone production so it will therefore allow you to return to normal in terms of hormone levels. A stack of IGF, PGF2a, HCG, and clomid would be a good bridge stack and would allow your body to return to normal and still allow you to retain and make new gains.

IGF is a research drug, it hasn't been approved by the FDA for use as a pharmaceutical and it is currently being researched for nerve tissue repair, possible burn victims, and also as a possible aid in muscle wasting for AIDS patients. There are many different analogs of IGF available, instead of mentioning them all, I will simply mention the two most common and the most effective. Regular recombinant IGF is one of the two, it is also the more expensive and the least effective. Regular IGF only has a half-life of about 10-20 minutes in the human body and is quickly destroyed, it can be combined with certain binding proteins to extend the half-life, but it is not a very simple procedure and there is a more effective and less expensive version available. The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."

"Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF's."

It is also not as expensive since a media grade version is available which is sufficient for bodybuilding use. There is also a receptor grade available but it is VERY expensive and the only noticeable difference between the two would only be able to be noticed in a laboratory setting. The price on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per milligram depending on the source, be wary of black market ******s of any IGF since it is a VERY difficult item to obtain. As mentioned IGF is a research product and is only available from a few laboratories in the world and is only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.

Any form of IGF is ONLY supplied in a lyphosized form, which means a dry powder state. NEVER PUCHASE PRE-DILUTED LIQUID IGF!!!! There is no such product made anywhere in the world and even if there were real IGF ever present in the vial it would all be dead by the time you receive it. IGF is a very delicate peptide and must be diluted by yourself, where you have access to a refrigerator and freezer. There has also been a lot of talk by certain sources claiming to have IGF made by the Eli Lilly company, to clear things up Lilly is a pharmaceutical company and as stated IGF is a research drug and has not yet been approved, Lilly does not and never has manufactured research drugs for retail sale.

The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results, and in fact several top bodybuilders use the 20mcg/day dosage and are pleased with the results. IGF is most effective when administered subcutaneously and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.

Another frequently asked question of IGF refers to the real world results, in terms of pure weight gain don't expect to gain 5 lbs. a week like you may off of anadrol or a similar steroid. The only weight you will gain from IGF use is pure lean muscle tissue, with steroids most of the weight gained is water weight. With an effective dosage you can expect to gain 1-2 lbs of new lean muscle tissue every 2-3 weeks and these effects can be increased with the use of testosterone, anabolic steroids, and insulin use. Increased vascularity is also very common, people report seeing veins appear where they never have before. And yet another effect reported is the ability to stay lean while bulking with heavy dosages of steroids and TONS of food while on an IGF cycle, this is perhaps the most pleasing effect. Increased pumps are also noticeable almost immediately, the pumps can almost become painful, pumps are even noticeable when doing cardio.

Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities. If you can find a trustworthy source and you use it correctly it can be a VERY useful tool in your bodybuilding drug ****nal.


Long™R3IGF-I is an analog of human IGF-I.
· It is a superior alternative to insulin in serum-free media.
· It increases protein production by cells in culture medium.
· It increases cell viability by inhibiting apoptosis.
· It has a longer half-life in cell culture than insulin.
· It is readily available.
· There is secure and ample manufacturing capacity at GroPep Limited.
· No animal- or human- derived material is used in the manufacture or storage of Long™R3IGF-I.
· Long™R3IGF-I is already being used in the manufacture of three (3) biopharmaceuticals approved by FDA and EMEA.

Frequently Asked Questions

What cell types will respond to Long™R3IGF-I?
All cells that have a Type I IGF receptor will potentially respond. Most commercially used cells including CHO, fibroblasts and hybridomas have a type I IGF receptor. All cells which respond to pharmacological concentrations of insulin (>1 mg/liter) will respond to Long™R3IGF-I (10-50 mg/liter).

Is storage of the stock solution at 4°C acceptable?
Yes

How long is the stock solution stable for under these storage conditions?
Liquid stability data shows that Long™R3IGF-I is stable for 3 years (-20°C to 37°C). Therefore, the stock solution should be stable at 4°C for 3 years.

What type of preparation is available?
Liquid formulation, preferable for GMP production.
Freeze dried preparation.

Is Long™R3IGF-I stable?
Re-test date for freeze-dried peptide is 3 years. Liquid formulation stability studies have recently been completed. It is stable for 3 years (-20°C to +37°C). We have data indicating stability in media at 4°C for 1 year.

Here is an article written by a self-experimenter.

December 15, 2000

Answer: What a perfect question! You actually have talked to just the right person. I have a business associate that worked for the company that produces this in Australia. Several years ago, I ordered 10mg of Long R3 IGF-1 and used it for several months. What I found out was truly amazing.

Before I tell you about my results, let me tell you that if you are going to use IGF-1 then make sure it is the Long R3 version! Let me explain. Regular IGF-1 like what is produced in your body is transported around connected to binding proteins. There are quite a few of these and their main purpose is to grab ahold of the IGF-1 peptide and keep it from being quickly degraded. Without these binding proteins, all of the IGF-1 would be metabolized in the body within a few minutes. The problem (at least it seems like a problem but might actually be a good thing) is that these binding proteins basically prevent the IGF-1 from performing its function. As long as IGF-1 is attached to the binding protein it cannot do the cool stuff that it wants to do. Regular IGF-1 must be released from its binding protein in order to accomplish its mission. Part of the problem is that much of the IGF-1 is degraded before it is released (seems like much is wasted doesn’t it?)

With Long R3 IGF-1 this problem doesn’t exist. Understand that the Long R3 version does not bind to the various binding proteins. It is free to move throughout your body and immediately start doing all the cool stuff that it wants to do. Again, understand that the Long R3 version is several orders of magnitude stronger than regular IGF-1.

If you would happen to use regular IGF-1, you would need several milligrams per day in order to get the desired effect. With the Long R3 version, you need only microgram quantities. Long R3 is also inherently MUCH cheaper to produce. What I am saying is that for the average person, regular IGF-1 is not practical-it is too expensive and you need to use too much. With Long R3 IGF-1, the price to results ratio is pretty good!

Something else I want to explain is how I went about preparing it for injection into my body. Unfortunately, this is not easy and the average person will have a hard time doing it. At the time, I worked in a sophisticated lab which had all of the necessary equipment. I ordered 10mg of Long R3 IGF-1 and it came in a single flip-top vial. 10mg might not seem like much but believe me, when it comes to Long R3 IGF-1, it is a ton! Some people might say to just add saline to the vial, keep it in the fridge and inject it when necessary. However, this will not work well because the IGF-1 is not highly stable and will degrade in an aqueous environment. 10mg was enough for many months and I needed a way that would allow the IGF-1 to remain potent during this entire time. I did my research and developed my method. I ordered what is known as microvials and sterilized them. I then diluted the IGF-1 with sterile water and added just a tad of acid to increase stability. Although it took quite a while, I then used a micropipette and alliquotted an amount of solution that contained 50mcg into one of my microvials. I closed the microvial and then froze it in a deep freezer. When I was ready to inject, I took out one or more of my microvials, thawed it out, combined it with saline and injected it.

When I first started taking Long R3 IGF-1, I used 50mcg every other day. Amazingly, within days, I started noticing some effects in my body. I felt super hungry all of the time and just felt “anabolic”. I can’t describe this feeling except to say that it was very similar to being on anabolic steroids (I wasn’t on at the time). Within one month, I gained almost 17 pounds of fairly lean mass! After the first month, something happened though and I noticed that it didn’t seem to be working that well. I upped the dosage several times over the next month to keep up the desired effects. On the third month, I was using several hundred micrograms per day but wasn’t noticing any further gains. All in all, I gained about 20 pounds of pretty solid mass!

Please notice that almost all of my gains were within the first month of taking the Long R3 IGF-1. After this first month, my gains slowed down considerably and eventually stopped altogether even though I was taking high dosages. Why did this happen?

From all of my research, I suppose one of two things might have happened to prevent me from making further gains. What I truly suspect is that the Long R3 IGF-1 downregulated the amount of binding proteins being produced by my body (research confirms this). When I first started to inject the IGF-1, I was supplementing my own body’s IGF-1. I not only had my own IGF-1 working throughout the day but I had the potent surges of Long R3 IGF-1 that I would inject. Over time though, the binding proteins were downregulated. Of course my body continued to produce some (albeit less) IGF-1, however, because there were very little or no binding proteins it was quickly degraded. From what I can tell, I was in a state where 95% of the day my body did not have the benefits of IGF-1. Basically, it got what it got when I injected the Long R3 version.

The other possibility is that I built up antibodies to the Long R3 IGF-1 which basically sought out and destroyed what I injected. Although possible, I don’t believe this actually happened because it is not supported by research. I have seen no evidence which suggests that Long R3 IGF-1 causes antibody production.

To fix the above problem, one would have to cycle the Long R3 IGF-1. The best thing would probably be to take it every other month. This would allow your own body’s IGF-1 and binding proteins to return to normal.

Overall, I had a good experience with Long R3 IGF-1. The results were different than with steroids. I have noticed that steroids cause preferential growth of certain muscles, especially those that are stressed (as in lifting). The IGF-1 though seemed to cause my entire body to get a little thicker. I guess IGF-1 is less compensatory in nature and exerts a more whole-body anabolicity.

Would I recommend IGF-1? To the right person who is very careful and knows what he’s doing and has a good background in the sciences and has access to a good lab, YES! However, you can tell that I have listed many prerequisites to using it. For the average Joe, I believe is is just too complicated to be safe.

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Pscarb

i have used IGF-Lr3 on a few occasions with great results however it is not a quick fix for those who don't want to use AAS or have non or little experiance with AAS..

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Ironman

Now im confused the second description makes out like its a gift from God and makes me want to run out and buy it all up!

Pscarb - couple of questions

Is it hard to source - ie get the real thing

Is it hard to prepare

Is it particulary expensive - or is it within the realms of the normal mans wage?

the_gre8t_1ne

http://www.muscle-research.com/

All the IGF u want m8 as they make it! not expensive compared to GH and all the effects and better

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If you smelalalalalalooouuuu
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the gre8t 1ne.......is cooking!?
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also find me at
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Great White

Muscle Research are sponsors of the board mate.

There is a Forum dedicated to them ;)

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Pscarb

ironman
i posted up both articles because they have diffrent thoughts on IGF i love the stuff and it does work however it is not a drug to be used by inexperianced Bodybuilders in a way of building without AAS.

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Ironman

Pscarb, how do you personally take it? Do you take it along with your cycles or do you us eit to bridge?

Pscarb

i have done both with good results both ways you will get more mass whilst on AAS but you will maintain if not build new muscle whilst using it as a bridge or part of PCT

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