ARNIE

look at this....
ACE-031 (Muscle Growth)

ACE-031, the lead product in Acceleron’s muscle program, is being developed to treat diseases involving the loss of muscle mass, strength and function in diseases including muscular dystrophy, amyotrophic lateral sclerosis and cancer-related muscle loss. ACE-031 works by inhibiting myostatin and other negative regulators of muscle mass thereby freeing the body to rebuild muscle tissue.
Myostatin Limits the Production of Muscle
There are natural checks and balances in many processes in the human body, including the process that controls formation of muscle mass. Myostatin, also known as Growth Differentiation Factor-8 (GDF-8), works as a negative regulator of muscle mass, essentially limiting the body’s ability to add muscle. Over-expression of myostatin has been shown to cause a loss in muscle mass and strength, whereas inhibition of myostatin results in the selective increase in skeletal muscle mass and strength.

There are several examples in animals with genetic mutations that lead to low levels of myostatin, resulting in huge increases in muscle mass. For instance, the photo above shows the myostatin-deficient Belgian Blue breed of cattle, which despite being otherwise normal, have tremendously increased muscle mass.
ACE -031: A Decoy Myostatin Receptor
ACE-031 was specifically developed to inhibit myostatin and other negative regulators of muscle mass and strength. The reduction of myostatin would enable the body to add muscle mass to muscles weakened by disease. ACE-031 is a biotherapeutic based on the activin receptor type IIB (ActRIIB), which is the natural receptor for myostatin and other negative regulators of muscle mass. Acceleron scientists have engineered the product to combine the portion of ActRIIB that binds tightly to myostatin with a component of an antibody molecule that allows ACE-031 to circulate freely throughout the body.
Inhibiting the Inhibitor: Using ACE-031 to Grow New Muscle
ACE-031 acts as a decoy receptor and binds myostatin before it is able to bind with ActRIIB on the surface of muscle cells. Binding prevents myostatin signaling, thereby allowing normal muscle formation processes to occur, resulting in increased muscle mass and strength.
Recent studies with ACE-031 suggest that targeting myostatin may be a powerful way to increase muscle mass and improve physical function. In a range of animal models of muscle disease, including models of muscular dystrophy, amyotrophic lateral sclerosis, glucocorticoid-induced muscle loss and age-related muscle loss (sarcopenia), ACE-031 increased muscle mass, strength and physical function.
ACE-031 Clinical Development Program
Acceleron is developing ACE-031 to treat muscle-loss caused by:

• Muscular Dystrophy (MD)
• Amyotrophic Lateral Sclerosis (ALS)
• Cancer-Related Muscle Loss

By restoring skeletal muscle mass, strength and function, ACE-031 may offer hope to patients with these diseases. Acceleron expects to enter clinical trials with ACE-031 in early 2008.

Magic Torch

Man the pic of the Cow made me hungry!

ARNIE

hungry for love?

ARNIE

would you get some if it becomes available,sounds good.

tony 33

if it does bacome avaliable that aint bbing its pill popping ...anyone will take and say they trained for 4yrs..:crazy:.should only be used in medical world imo..

GTT

This thing will throw bodybuilding on its head.

ah24

Would completely ruin BBing

ARNIE

well theres been talk of this for a while,like a wonder drug,the bbers of the next 20 years could be real freaks lol...

ARNIE

i read the reason that some bbers were as big as they are eg genetic freaks so to say was because of a defficiency in the myostatin levels or gene.

Delhi

Or completley save BBing depending on your perspective!!

Say this drug did become avaliable, and say it did do what it says it will, that situation "Could" be the trigger for the feds to finally reverse the trend in SIZE at all costs and may possibly lead to a return to a more asthetic physique?

A return to the golden age??????

TaintedSoul

I think I would loose if Feds start dictating that people are getting too big muscle wise.

But tall chaps with myostatin inhibitors would be awesome!!

Chris4Pez

:bump: as at work lol

megatron

Yes, but when is it going to be available?

And who would try it? - not me

megatron

Well, someone could contact these guys and beg for some:

Acceleron Pharma
Steven Ertel, 617-520-1334
Vice President, Business Development
or
Media:
Suda Communications
Paul Kidwell, 617-296-3854

dom1986

looks good to me