Alcohol and testosterone. This study shows an increase in tes levels. - UK-Muscle Body Building Community

winger · 13-03-2004, 04:59 PM

Even though testosterone is often referred to as a "male sex hormone," it is in actuality common to both genders of animals and humans. The overwhelming majority of research conducted in the past 25 years in both animals and humans has found that alcohol inhibits testosterone secretion. However, a new study in the January issue of Alcoholism: Clinical & Experimental Research has found that acute administration of alcohol can induce a rapid increase in plasma and brain concentrations of testosterone in some rodents.

"We have demonstrated that there are very different results in the way two different groups of male rats form testosterone after acute administration of alcohol," said Robert H. Purdy, senior staff scientist in the department of neuropharmacology at The Scripps Research Institute and senior author of the study. "These differences in animals may reflect similar individual differences in humans, and provide new insights for understanding individual differences in the behavioral and endocrine pathology associated with alcohol abuse."

Fourfold Increase
Researchers injected either alcohol or 1,1-dideuteroethanol (2 g alcohol/kg body weight) into the abdominal cavities of two groups of rats, 30 un-operated and 24 adrenalectomized and castrated (ADX/GDX) Wistar males. 1,1-dideuteroethanol is a nonradioactive form of alcohol in which two of the hydrogen atoms on carbon atom #1 of ethanol have been replaced by deuterium atoms, which can then be traced.

Study authors used mass spectrometry, a very precise measure of the mass and structure of compounds derived from extracts of tissues and body fluids, to determine both the amount of neuroactive steroids present and the degree of deuterium incorporation into specific neuroactive steroids isolated from brain samples.

They found that concentrations of testosterone increased fourfold in the frontal cortex and threefold in the plasma of the un-operated rats 30 minutes after alcohol administration. ADX/GDX rats had testosterone concentrations that were only five percent of those found in the un-operated rats following alcohol administration. Tracing the effects of 1,1-dideuteroethanol demonstrated that alcohol oxidation is directly linked to testosterone biosynthesis.

Unanticipated Results
"Our finding of a direct link between alcohol administration and the level of the neuroactive steroid testosterone in the brain of these experimental animals was unanticipated from prior studies with another species of rats," Purdy said.

"Although many other studies clearly demonstrate that chronic consumption of high dosages of alcohol appears to be consistently inhibitory and suppresses reproductive function," said Dennis D. Rasmussen, research associate professor in the department of psychiatry at the University of Washington, "this study raises the possibility that episodes of alcohol consumption may also at least temporarily increase testosterone levels, with the direction of the response likely being dependent upon a variety of factors, including dosage and personal characteristics.

"This particular dosage produced blood alcohol levels and behavioral responses consistent with intoxication. So, alcohol consumption, under at least some conditions and by at least some individuals, may acutely stimulate testosterone levels in the plasma and brain of both males and females and thus could elicit some of the behavioral effects associated with increased testosterone levels, such as increased libido or aggression."

The Role of Testosterone
Rasmussen added that these findings join those of two other studies in which alcohol administration increased plasma testosterone levels in a gender- and dose-dependent manner. "Together these studies are important," he said, "because they illustrate that what has become a largely accepted principal - that alcohol consumption inhibits plasma testosterone levels and reproductive function - is not universally true."

Rasmussen suggested that future research build upon and add to previous findings regarding alcohol's effects on testosterone. "It would be important to determine whether lower dosages of alcohol, which do not induce rapid pronounced intoxication and ataxia, would also produce the acute increase in testosterone, and whether this response to lower dosages would be consistent across different strains of rats. Also, does tolerance develop with repeated administrations?

"Does this increase in testosterone occur following elective self-administration of alcohol? Finally, and probably most interesting, what role might the demonstrated changes in testosterone play in behavioral responses to acute ethanol consumption? Are there gender differences in these responses? And, if the responses do occur in females, are they different during different stages of a woman's cycle?"

Co-authors of the Alcoholism: Clinical & Experimental Research paper included: Ahmed A. Alomary of the Department of Neuropharmacology at The Scripps Research Institute, and the Veterans Affairs Healthcare Center, and Veterans Medical Research Foundation in San Diego Diego (Dr. Alomary currently resides in Jordan); Laura E. O'Dell, George F. Koob, and Monique Vallée of the Department of Neuropharmacology at The Scripps Research Institute (Dr. Vallée currently resides in France); and Robert L. Fitzgerald of the Veterans Affairs Healthcare Center, the Veterans Medical Research Foundation, and the Department of Pathology at the University of California in San Diego. The study was funded by the National Institute on Alcohol Abuse and Alcoholism.

miami797 · 27-03-2004, 04:07 PM

so this means that if hackskii was a rat he would be one big ass rat? and without test or hgh?

on the serious side, if alchohol helps release test or whatever way that science talk put it..is that why alot of men get alot more aggressive after a few drinks???

winger · 27-03-2004, 04:16 PM

Quote:

Originally posted by miami797
so this means that if hackskii was a rat he would be one big ass rat? and without test or hgh?

on the serious side, if alchohol helps release test or whatever way that science talk put it..is that why alot of men get alot more aggressive after a few drinks???

Yea that is what they are saying. Suppose it is true how can it bump up tes levels so fast. I dont think anything can bump tes levels that fast. Say you take an oral like d-bol does it make you agressive later that night? Who knows. I just thought it was interesting.

miami797 · 27-03-2004, 04:21 PM

its very interesting....

another interesting alchie tid bit i found out about working in an animal hospital....when a cat drink anti-freeze the only thing that will save its life is pure grain alch IV...it does something to the crystals that form in the cat...

winger · 27-03-2004, 04:29 PM

Oh wow. I didn't think there was a fix for that. So what are you saying is Hackskii can drink antifreeze?

miami797 · 27-03-2004, 04:34 PM

only if he's a pus$y...cat that is

winger · 27-03-2004, 04:44 PM

He's as smart as one though.:p
He told me he is strong as a bull and twice as smart.

T-man · 27-03-2004, 08:31 PM

Hi guys, Sorry winger I have not got time to read all that at the moment, but I heard of a study of alcohol and test levels and it said that it increased womens levels and lowered mens.

winger · 28-03-2004, 02:00 AM

There could be some truth to that. I dont know why but most women get so horney with alcohol. Thank God for that.

It gives guys like me a chance at getting laid. Oh sorry brits. It gives guys like me a chance to shag the birds.

miami797 · 28-03-2004, 09:15 AM

just because we're on a uk board doesnt mean we have to go to their standard of english winger...

don't know if that rat thing can be 100% with humans though...certain animals react different to different things...just like we get tired if we take dyphenhydramine(benadryl) and if you give it to a dog they get like tony montana....plus even though dogs are much smaller then us they need 1mg per lb of body weight....where as a human no matter how big needs only 75mg..
dont know if thats useful to you...but its just an example of how things get different reactions so we never can tell by those lab animal tests

winger · 28-03-2004, 04:06 PM

Yea I agee with that.

Killerkeane · 31-03-2004, 04:52 PM

is there any alcahol in basset's jelly babies, i always get aggresive on those little bastards....

Mobster · 03-04-2004, 03:18 PM

The reality is far different. An increase in aggresion in males when drinking isn't as a result of increased 'test' but a lowering of inibitions (sp). A small amount of alcohol MAY increase 'test' but more and esp frequent use actually increase estrogen levels.

Studies like this are all well and good but basically BS. Prove it to yourselfs. Go and look at the actual physiques sported by winos. Malnutrition is rife and the fact that a big dominant male drunk might be the leader of the pack is more related to his natural testosterone levels and survival of the fittest than it is to him drinking the most and getting to be the biggest/most muscular.

Read the t-mag.com article (todays new update) re proof and evidence.

13-03-2004, 04:59 PM	#1 (permalink)
winger UK-Muscle Male Animal Join Date: Jul 2003 Location: Southern California, USA Posts: 10,315 Blog Entries: 1	Alcohol and testosterone. This study shows an increase in tes levels. Even though testosterone is often referred to as a "male sex hormone," it is in actuality common to both genders of animals and humans. The overwhelming majority of research conducted in the past 25 years in both animals and humans has found that alcohol inhibits testosterone secretion. However, a new study in the January issue of Alcoholism: Clinical & Experimental Research has found that acute administration of alcohol can induce a rapid increase in plasma and brain concentrations of testosterone in some rodents. "We have demonstrated that there are very different results in the way two different groups of male rats form testosterone after acute administration of alcohol," said Robert H. Purdy, senior staff scientist in the department of neuropharmacology at The Scripps Research Institute and senior author of the study. "These differences in animals may reflect similar individual differences in humans, and provide new insights for understanding individual differences in the behavioral and endocrine pathology associated with alcohol abuse." Fourfold Increase Researchers injected either alcohol or 1,1-dideuteroethanol (2 g alcohol/kg body weight) into the abdominal cavities of two groups of rats, 30 un-operated and 24 adrenalectomized and castrated (ADX/GDX) Wistar males. 1,1-dideuteroethanol is a nonradioactive form of alcohol in which two of the hydrogen atoms on carbon atom #1 of ethanol have been replaced by deuterium atoms, which can then be traced. Study authors used mass spectrometry, a very precise measure of the mass and structure of compounds derived from extracts of tissues and body fluids, to determine both the amount of neuroactive steroids present and the degree of deuterium incorporation into specific neuroactive steroids isolated from brain samples. They found that concentrations of testosterone increased fourfold in the frontal cortex and threefold in the plasma of the un-operated rats 30 minutes after alcohol administration. ADX/GDX rats had testosterone concentrations that were only five percent of those found in the un-operated rats following alcohol administration. Tracing the effects of 1,1-dideuteroethanol demonstrated that alcohol oxidation is directly linked to testosterone biosynthesis. Unanticipated Results "Our finding of a direct link between alcohol administration and the level of the neuroactive steroid testosterone in the brain of these experimental animals was unanticipated from prior studies with another species of rats," Purdy said. "Although many other studies clearly demonstrate that chronic consumption of high dosages of alcohol appears to be consistently inhibitory and suppresses reproductive function," said Dennis D. Rasmussen, research associate professor in the department of psychiatry at the University of Washington, "this study raises the possibility that episodes of alcohol consumption may also at least temporarily increase testosterone levels, with the direction of the response likely being dependent upon a variety of factors, including dosage and personal characteristics. "This particular dosage produced blood alcohol levels and behavioral responses consistent with intoxication. So, alcohol consumption, under at least some conditions and by at least some individuals, may acutely stimulate testosterone levels in the plasma and brain of both males and females and thus could elicit some of the behavioral effects associated with increased testosterone levels, such as increased libido or aggression." The Role of Testosterone Rasmussen added that these findings join those of two other studies in which alcohol administration increased plasma testosterone levels in a gender- and dose-dependent manner. "Together these studies are important," he said, "because they illustrate that what has become a largely accepted principal - that alcohol consumption inhibits plasma testosterone levels and reproductive function - is not universally true." Rasmussen suggested that future research build upon and add to previous findings regarding alcohol's effects on testosterone. "It would be important to determine whether lower dosages of alcohol, which do not induce rapid pronounced intoxication and ataxia, would also produce the acute increase in testosterone, and whether this response to lower dosages would be consistent across different strains of rats. Also, does tolerance develop with repeated administrations? "Does this increase in testosterone occur following elective self-administration of alcohol? Finally, and probably most interesting, what role might the demonstrated changes in testosterone play in behavioral responses to acute ethanol consumption? Are there gender differences in these responses? And, if the responses do occur in females, are they different during different stages of a woman's cycle?" Co-authors of the Alcoholism: Clinical & Experimental Research paper included: Ahmed A. Alomary of the Department of Neuropharmacology at The Scripps Research Institute, and the Veterans Affairs Healthcare Center, and Veterans Medical Research Foundation in San Diego Diego (Dr. Alomary currently resides in Jordan); Laura E. O'Dell, George F. Koob, and Monique Vallée of the Department of Neuropharmacology at The Scripps Research Institute (Dr. Vallée currently resides in France); and Robert L. Fitzgerald of the Veterans Affairs Healthcare Center, the Veterans Medical Research Foundation, and the Department of Pathology at the University of California in San Diego. The study was funded by the National Institute on Alcohol Abuse and Alcoholism. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

27-03-2004, 04:07 PM	#2 (permalink)
miami797 Feeling Slutty Join Date: Feb 2004 Posts: 1,440	so this means that if hackskii was a rat he would be one big ass rat? and without test or hgh? on the serious side, if alchohol helps release test or whatever way that science talk put it..is that why alot of men get alot more aggressive after a few drinks??? __________________ one in the pink. two in the stink.

27-03-2004, 04:21 PM	#4 (permalink)
miami797 Feeling Slutty Join Date: Feb 2004 Posts: 1,440	its very interesting.... another interesting alchie tid bit i found out about working in an animal hospital....when a cat drink anti-freeze the only thing that will save its life is pure grain alch IV...it does something to the crystals that form in the cat... __________________ one in the pink. two in the stink.

27-03-2004, 04:29 PM	#5 (permalink)
winger UK-Muscle Male Animal Join Date: Jul 2003 Location: Southern California, USA Posts: 10,315 Blog Entries: 1	Oh wow. I didn't think there was a fix for that. So what are you saying is Hackskii can drink antifreeze? __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

27-03-2004, 04:34 PM	#6 (permalink)
miami797 Feeling Slutty Join Date: Feb 2004 Posts: 1,440	only if he's a pus$y...cat that is __________________ one in the pink. two in the stink.

27-03-2004, 04:44 PM	#7 (permalink)
winger UK-Muscle Male Animal Join Date: Jul 2003 Location: Southern California, USA Posts: 10,315 Blog Entries: 1	He's as smart as one though.:p He told me he is strong as a bull and twice as smart. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

27-03-2004, 08:31 PM	#8 (permalink)
T-man Gym Addict Join Date: Sep 2003 Location: England Posts: 253	Hi guys, Sorry winger I have not got time to read all that at the moment, but I heard of a study of alcohol and test levels and it said that it increased womens levels and lowered mens. __________________ You can't grow without pain!

28-03-2004, 02:00 AM	#9 (permalink)
winger UK-Muscle Male Animal Join Date: Jul 2003 Location: Southern California, USA Posts: 10,315 Blog Entries: 1	There could be some truth to that. I dont know why but most women get so horney with alcohol. Thank God for that. It gives guys like me a chance at getting laid. Oh sorry brits. It gives guys like me a chance to shag the birds. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

28-03-2004, 09:15 AM	#10 (permalink)
miami797 Feeling Slutty Join Date: Feb 2004 Posts: 1,440	just because we're on a uk board doesnt mean we have to go to their standard of english winger... don't know if that rat thing can be 100% with humans though...certain animals react different to different things...just like we get tired if we take dyphenhydramine(benadryl) and if you give it to a dog they get like tony montana....plus even though dogs are much smaller then us they need 1mg per lb of body weight....where as a human no matter how big needs only 75mg.. dont know if thats useful to you...but its just an example of how things get different reactions so we never can tell by those lab animal tests __________________ one in the pink. two in the stink.

28-03-2004, 04:06 PM	#11 (permalink)
winger UK-Muscle Male Animal Join Date: Jul 2003 Location: Southern California, USA Posts: 10,315 Blog Entries: 1	Yea I agee with that. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.

31-03-2004, 04:52 PM	#12 (permalink)
Killerkeane The Geezer Join Date: Nov 2003 Location: Somerset although im not proud lol. Posts: 2,978	is there any alcahol in basset's jelly babies, i always get aggresive on those little bastards.... __________________ Fortes Fortuna Paratus Mens-Fortune favours the prepared mind.:amen:

03-04-2004, 03:18 PM	#13 (permalink)
Mobster Newbie Trainer Join Date: Apr 2004 Location: London Posts: 91	The reality is far different. An increase in aggresion in males when drinking isn't as a result of increased 'test' but a lowering of inibitions (sp). A small amount of alcohol MAY increase 'test' but more and esp frequent use actually increase estrogen levels. Studies like this are all well and good but basically BS. Prove it to yourselfs. Go and look at the actual physiques sported by winos. Malnutrition is rife and the fact that a big dominant male drunk might be the leader of the pack is more related to his natural testosterone levels and survival of the fittest than it is to him drinking the most and getting to be the biggest/most muscular. Read the t-mag.com article (todays new update) re proof and evidence. __________________ To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. a guide to shutting hand grippers. To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts. - a proud sponsor of UK-Muscle. Now selling our newly arrived Classic Black T-shirts To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.