Anti-estrogens Arimidex,Clomid

[Jon Boy Wales]

Anti-estrogens
Arimidex- Oral; Substance:Anastrozole

Effective dosage:
0.25 - 1.0 mg/day

Side effects:
In high dosages it might prove liver toxic.

Additional comments:
Active Life: 48 hours
Drug Class: Anti-estrogen/inhibitor
Arimidex detailed information:
Arimidex is not a steroid. It is a tablet form anti-aromitase that is used by many body builders to help prevent bloating (edema) and Gynecomastia (bitch tit) associated with the use of testosterone and androgens.
It can be used in place of Nolvadex ,Clomid, etc. Bodybuilders are using around .25mg to 1mg per day or .5mg to 1mg every other day and are having good success with it. The FDA approved uses are for the treatment of breast cancer in post-menopausal women with disease progression following tamoxifen therapy. Hypersensitivity to anastrozole are reasons not to use this drug.
If you have these problems please inform your doctor. Common side effects are: shortness of breath, dizziness, diarrhea, vomiting, headache, hat flashes, weakness, cough, dry mouth, skin rash, sweating, abdominal pain and bone pain. Some less common symptoms are vaginal bleeding, weight gain, tiredness, chills, fever, breast pain, and itching. In case of an overdose, it is recommended to contact your poison control center.
Anastrozole (Arimidex) is the aromatase inhibitor of choice. The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.
As an aromatase inhibitor, Arimidex's mechanism of action -- blocking conversion of aromatizable steroids to estrogen -- is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others. During a cycle, if using Arimidex, there is generally no need to use Clomid as well, but (as mentioned in the section on Clomid) there may still be benefits to doing so.With moderate doses of testosterone 0.5 mg/day is usually sufficient and in some cases may be too much.

Clomid - Oral; Substance: Clomiphene Citrate

Effective dosage:
25-100 mcg/day

Additional comments:
Drug Class: Synthetic thyroid hormone.
Comments: Significant suppression of Thyroid function during use.

Arimidex detailed information:

Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.
While it has been claimed that Clomid "stimulates" production of LH and therefore of testosterone, in fact Clomid's activity is achieved not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.
Clomid also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue. This is very significant for endurance athletes but is not very significant, if at all significant, with reasonable weight training. Clomid does not perceptibly affect gains of the weight trainer either favorably or adversely in my experience.
The drug seems to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can yield depression or PMS-like symptoms, but for most users there is no significant effect either way.
The claim that duration of intake should not exceed 10-14 days is incorrect. Clinical studies with male patients have been for periods of a year or longer. This error probably originates from the fact that, for use in women, due to the menstrual cycle there would obviously be no point in trying to stimulate ovulation all four weeks of the month. Thus, use in women is limited to 10-14 days. That limitation is not because of toxicity.
Clomid is in fact useful throughout a cycle if aromatizable drugs are being used. We do think however that to be conservative, one should use it no more than 2/3 of the time throughout the year or a little less.