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**hackskii** · 17-12-2003, 08:26 PM

Zinc status and serum testosterone levels of healthy adults.
Ananda S. Prasad, Mantzoros CS, Beck FWJ, Hess JW, Brewer GJ.
From the Department of Internal Medicine, Division of Hematology-Oncology, Wayne State University, School of Medicine, Detroit Michigan
Departments of Human Genetics and Internal medicine, The University of of Michigan Medical Center, Ann Arbor, Michigan, and Division of Endocrinolofy, Department of Internal Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Ma. USA
Nutrition, 12(5):344-8 1996

Zinc deficiency is prevalent throughout the world, including the USA. Severe and moderate deficiency of zinc is associated with hypogonadism in men. However, the effect of marginal zinc deficiency on serum testosterone concentration is not known. We studied the relationship between cellular zinc concentrations and serum testosterone cross-sectionally in 40 normal men, 20 to 80 y of age. In four normal young men (27.5+/- 0.5 y), we measured serum testosterone before and during marginal zinc deficiency induced by restricting dietary zinc intake. We also measured serum testosterone in nine elderly men (64 +/- 9 y) who were marginally zinc deficient before and after 3 to 6 mo of supplementation with 459 mumol/ d oral zinc administered as zinc gluconate. Serum testosterone concentrations were significantly correlated with cellular zinc concentrations in the cross-sectional study (lymphocyte zinc versus serum testosterone, r = 0.43, p = 0.006; granulocyte zinc versus serum testosterone, r = 0.30, p = 0.03).

Dietary zinc restriction in normal young men was associated with a significant decrease in serum testosterone concentrations after 20 weeks of zinc restriction (baseline versus post-zinc restriction mean +/- SD, 39.9 +/- 7.1 versus 10.6 +/- 3.6 nmol/L, respectively; p = 0.005). Zinc supplementation of marginally zinc-deficient normal elderly men for six months resulted in an increase in serum testosterone from 8.3 +/- 6.3 to 16.0 +/- 4.4 nmol/L (p = 0.02). We conclude that zinc may play an important role in modulating serum testosterone levels in normal men.

(This study was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant; Food and Drug Administration (FDA) Grant; NIH/National Cancer Insitute Grant; Clinical Research Center Grant; the W.K. Kellog Foundation; and Labcatal Laboratories.)

17-12-2003, 08:26 PM	#7 (permalink)
hackskii UK-Muscle Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 23,717	Zinc status and serum testosterone levels of healthy adults. Ananda S. Prasad, Mantzoros CS, Beck FWJ, Hess JW, Brewer GJ. From the Department of Internal Medicine, Division of Hematology-Oncology, Wayne State University, School of Medicine, Detroit Michigan Departments of Human Genetics and Internal medicine, The University of of Michigan Medical Center, Ann Arbor, Michigan, and Division of Endocrinolofy, Department of Internal Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Ma. USA Nutrition, 12(5):344-8 1996 Zinc deficiency is prevalent throughout the world, including the USA. Severe and moderate deficiency of zinc is associated with hypogonadism in men. However, the effect of marginal zinc deficiency on serum testosterone concentration is not known. We studied the relationship between cellular zinc concentrations and serum testosterone cross-sectionally in 40 normal men, 20 to 80 y of age. In four normal young men (27.5+/- 0.5 y), we measured serum testosterone before and during marginal zinc deficiency induced by restricting dietary zinc intake. We also measured serum testosterone in nine elderly men (64 +/- 9 y) who were marginally zinc deficient before and after 3 to 6 mo of supplementation with 459 mumol/ d oral zinc administered as zinc gluconate. Serum testosterone concentrations were significantly correlated with cellular zinc concentrations in the cross-sectional study (lymphocyte zinc versus serum testosterone, r = 0.43, p = 0.006; granulocyte zinc versus serum testosterone, r = 0.30, p = 0.03). Dietary zinc restriction in normal young men was associated with a significant decrease in serum testosterone concentrations after 20 weeks of zinc restriction (baseline versus post-zinc restriction mean +/- SD, 39.9 +/- 7.1 versus 10.6 +/- 3.6 nmol/L, respectively; p = 0.005). Zinc supplementation of marginally zinc-deficient normal elderly men for six months resulted in an increase in serum testosterone from 8.3 +/- 6.3 to 16.0 +/- 4.4 nmol/L (p = 0.02). We conclude that zinc may play an important role in modulating serum testosterone levels in normal men. (This study was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant; Food and Drug Administration (FDA) Grant; NIH/National Cancer Insitute Grant; Clinical Research Center Grant; the W.K. Kellog Foundation; and Labcatal Laboratories.) __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.