Quote:
Originally Posted by Macro  adiposity is related to both genes and hormones as well as environmental factors. Estrogen and Insulin play primary roles in reducing availability of stored fats (estrogen via upregulation of Alpha2 adrenoceptor- see article below and insulin via direct inhibition of lipolysis as well as adipogenesis-- thus the importance of maintaing good insulin sensitivity and blood glucose levels) http://www.afboard.com/forum/anafit-...-estrogen.html |
More 'oestrogen is bad' internet rumour bull****e with no references.
It also doesn't consider leptin, ghrelin, peptide (sorry can't remember full name right now), dopamine reward system.
Sorry, not so simple, it is a case of someone taking one wee bit of physiology out of context.
The concept of eliminating oestrogen to increase fat loss is one of those bodybuilding myths, far too simplistic and simply outdated.
Gao Q, Horvath T. Crosstalk between estrogen and leptin signaling in the hypothalamus. Am J Physiol Endocrinol Metab. 2008 Mar 11 [Epub ahead of print]
Comparative Medicine, Yale University, New haven, Connecticut, United States.
Obesity, characterized by enhanced food intake (hyperphagia) and reduced energy expenditure that results in the accumulation of body fat, is a major risk factor for various diseases including diabetes, cardiovascular disease and cancer.
In the United States, more than half of adults are overweight and this number continues to increase (Flegal et al., 2002). The adipocyte secreted hormone, leptin, and its downstream signaling mediators play crucial roles in the regulation of energy balance.
Leptin decreases feeding while increasing energy expenditure and permitting energy-intensive neuroendocrine processes (such as reproduction). Thus, leptin also modulates the neuroendocrine reproductive axis.
The gonadal steroid hormone, estrogen, plays a central role in the regulation of reproduction and also contributes to the regulation of energy balance.
Estrogen deficiency promotes feeding and weight gain, and estrogen facilitates and to some extent mimics some actions of leptin.
In this review, we examine the function of estrogen and leptin in the brain, with a focus on mechanisms by which leptin and estrogen cooperate in the regulation of energy homeostasis. Key words: estradiol, leptin, crosstalk.