Quote:
Originally Posted by Pscarb  i disagree mate i have used both and found better results with T3, can i ask this enzyme what is considered to much? you would think it would be normal levels hence the cut off so whats the point if the body will cut off the conversion ??
that article is interesting and i changed my method after reading it but found the results where not as good.....so switch back to T3 which is in my opinion better whuith GH |
The enzymes he's referring to are the deiodinases which are responsible for the conversion of T4 to T3 in the cells of peripheral tissues (liver, muscle etc.) But I think a lot of people have got themselves muddle up concerning these and T3 and GH etc.
Think of T4 just as a long chain of iodine and tyrosine which can be broken down or shortened to make T3. The deiodinase enzymes do this. This is important as only approx 3% of T3 is released from the thyroid and the rest made in the tissues from T4. If we make too much T3, deiodinase activity slows and our T3 levels fall back to normal. This is how taking T3 will supress natural production albiet, in most cases, temporarily.
However, the deiodinases also act on the pituitary and are important for GH production.
So the theory is that taking T3 will mess with GH production, as high T3 levels cause downregulation of one type of enzyme linked to GH production.
BUT administered GH doesnt come from the pituitary, it comes from..well...China mainly lol. So,
administered T3 and GH will have
no detrimental effect on one another because it's endogenous GH (made inside us) that is affected by high levels of T3.