Originally Posted by Truewarrior1

Arachidonic Acid Causes Sudden Death in Rabbits
Melvin J. Silver 1, Willis Hoch 1, James J. Kocsis 1, Carol M. Ingerman 1, and J. Bryan Smith 1

1 Cardeza Foundation and Departments of Pharmacology and Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Injection of sodium arachidonate (1.4 milligrams per kilogram) into the marginal ear veins of rabbits caused death within 3 minutes. Histological examination showed platelet thrombi in the microvasculature of the lungs. Rabbits were protected from the lethal effects of arachidonic acid by pretreatment with aspirin. Fatty acids closely related to arachidonic acid did not cause death.

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Stroke in rats produced by carotid injection of sodium arachidonate
TW Furlow Jr and NH Bass

Unilateral cerebrovascular occlusion was produced in heparinized rats within 60 seconds after an injection of sodium arachidonate (in doses exceeding 0.45 milligram per kilogram) into the carotid artery. Electroencephalographic activity over the affected cerebral hemisphere was suppressed, and cerebral blood flow decreased by half. Microscopic examination revealed complete obstruction of the hemispheric microcirculation by platelet aggregates.