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**hackskii** · 22-05-2006, 07:03 PM

I was sick since Saturday running a 103 temperature and felt like crap, I couldn’t get to the board and almost couldn’t get out of bed for that matter. Fever broke last night and today I feel a lot better (thank God).
Anyway a member asked a question is nolvadex hard on the liver, this question has been asked before and cookie suggested it was not the best thing for the liver and after a cycle liver enzymes can be elevated so I thought I would do a little research.
This is what I cam up with.
They are all copy and paste, well snips from articles really.

Is nolvadex hard on the liver?

Although tamoxifen can cause liver cancer in particular strains of rats, it is not known to cause liver cancer in humans. It is clear, however, that tamoxifen can sometimes cause other liver toxicities in patients, which can be severe or life threatening. Doctors may order blood tests from time to time to check liver function.

Another copy and paste:

In rats and mice, tamoxifen activates liver enzyme cytochrome p450 like most other chemical rcinogens. This originally led researchers to believe that tamoxifen would be a classic carcinogen. However, it was later shown that tamoxifen is metabolized differently in humans than in rats. Tamoxifen does not appear to be a liver carcinogen in humans. However, researchers in Japan did CT scans on the livers of 66 patients taking tamoxifen for three to five years, and found that 36% of them had a fatty liver. The condition was not readily detectable: liver enzymes were elevated in only about half of the women. The researchers recommended regular scans for women taking tamoxifen, yet neither the FDA nor Zeneca has alerted women.

What about Clomid (Clomiphene Citrate)?

Unless directed to do so by your doctor, do not use this medication if you have an uncontrolled thyroid or adrenal gland disorder, an abnormality of the brain such as a pituitary gland tumor, a liver disease or a history of liver problems, abnormal uterine bleeding of undetermined origin, ovarian cysts, or enlargement of the ovaries not caused by polycystic ovarian syndrome (a hormonal disorder causing lack of ovulation).

So with the above information I feel it might not be the best approach if you have liver problems to do SERM's but then again, we know orals arent good for us but do them anyway right?

If it was me, I get shutdown so hard, I would trade some liver damage over months of waiting to recover.

22-05-2006, 07:03 PM	#1 (permalink)
hackskii UK-Muscle Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 23,704	Is clomid or nolvadex bad on the liver? I was sick since Saturday running a 103 temperature and felt like crap, I couldn’t get to the board and almost couldn’t get out of bed for that matter. Fever broke last night and today I feel a lot better (thank God). Anyway a member asked a question is nolvadex hard on the liver, this question has been asked before and cookie suggested it was not the best thing for the liver and after a cycle liver enzymes can be elevated so I thought I would do a little research. This is what I cam up with. They are all copy and paste, well snips from articles really. Is nolvadex hard on the liver? Although tamoxifen can cause liver cancer in particular strains of rats, it is not known to cause liver cancer in humans. It is clear, however, that tamoxifen can sometimes cause other liver toxicities in patients, which can be severe or life threatening. Doctors may order blood tests from time to time to check liver function. Another copy and paste: In rats and mice, tamoxifen activates liver enzyme cytochrome p450 like most other chemical rcinogens. This originally led researchers to believe that tamoxifen would be a classic carcinogen. However, it was later shown that tamoxifen is metabolized differently in humans than in rats. Tamoxifen does not appear to be a liver carcinogen in humans. However, researchers in Japan did CT scans on the livers of 66 patients taking tamoxifen for three to five years, and found that 36% of them had a fatty liver. The condition was not readily detectable: liver enzymes were elevated in only about half of the women. The researchers recommended regular scans for women taking tamoxifen, yet neither the FDA nor Zeneca has alerted women. What about Clomid (Clomiphene Citrate)? Unless directed to do so by your doctor, do not use this medication if you have an uncontrolled thyroid or adrenal gland disorder, an abnormality of the brain such as a pituitary gland tumor, a liver disease or a history of liver problems, abnormal uterine bleeding of undetermined origin, ovarian cysts, or enlargement of the ovaries not caused by polycystic ovarian syndrome (a hormonal disorder causing lack of ovulation). So with the above information I feel it might not be the best approach if you have liver problems to do SERM's but then again, we know orals arent good for us but do them anyway right? If it was me, I get shutdown so hard, I would trade some liver damage over months of waiting to recover. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.