| Insulin resistance is usually a disorder of the elderly or obese. It basically means there is too much body for the amount of insulin produced. A drop in weight of 10-15% usually corrects this.
As for the cell surface receptor 'damage', I had thought that it was hydrogenated fats that 'block up' the glucose receptors.
There are 5 categories of glucose receptors, some are tissue specific, called GLUT 1 through 5.
GLUT 4 is stored in the cytoplasm of the cell and is transported to the cell surface under the influence of insulin and increases the uptake of glucose by 6-10 x.
GLUT 1 and 3 are always present on the cell surface, (GLUT 1 is on RBCs or red blood cells).
I do have loads more info on GLUT receptors, I love my cell and molecular biology.
Last edited by Tatyana; 24-03-2006 at 03:04 PM.
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