Originally Posted by Sylar

I got gyno from Deca whilst running an AI mate, and Tren too. Letro did jack sh1t, but Prami sorted it in just under 4 weeks.

Progestin up-regulates the prolactin receptor and it's protein (PRL-R mRNA) - If a individual is sensitive to prolactin elevation, or already has natty high levels of prolactin to start with, the chances of running into prolatin driven gyno when running Progestins will obviously be increased and no AI will be able to stop it. You'll need to Dopaminergic for that.

The AI should be able to reduce chances of progesterone derived gyno as progesterone seems to augment the stimulatory effect of oestrogen on the mammary tissue and there is a strong synergy between oestrogen and progesterone, so in theory progestagenic activity should be dramatically reduced if oestrogen is kept in check, but it won't do much for folk that are prolactin sensitive IMO.

I know two other members here who has had success with a Dopaminergic in reversing gyno whilst cycling 19-nors too. I believe "The Wolverine" was running Letro at 2.5mg ED for 4 weeks and saw zero improvement in gyno reduction - he introduced Prami and had great success within 4 weeks. Very similar to my experience with Prolactin driven gyno bud.