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**hackskii** · 17-09-2005, 02:27 PM

Just found this

P450 Metabolism
Managing Drug Interactions

Today, there are several updated p450 pharmacology charts on the Internet to help health providers assess potential drug interactions. The following chart tells you what p450 liver pathway is used by a given drug. If two drugs use the same pathway, they could affect one another. In general, a P450 substrate is any drug that uses the cytochrome p450 enzyme pathway. P450 inhibitors (INH) generally increase concentrations of other drugs. P450 inducers (IND) generally decrease concentrations of other drugs. P450 enzymes are classified using Roman numerals and letters. Almost half of all human drugs use p450 3A4; another 30 percent use p450 2D6.

Explanation of Table:
P450 substrate (S) is any drug that uses the Cytochrome p450 enzyme pathway.
P450 inhibitors (INH) generally increase concentrations of other drugs.
P450 inducers (IND) generally decrease concentrations of other drugs.
Some HIV drugs are both inducers and inhibitors.

Marijuana/Marinol: Uses p450 3A4, 2C9, 2C6 liver pathways. Specific interactions unknown.

Cocaine: Uses p450 liver pathways: Minor 2D6 inhibitor, 3A4 inducer, 2B1, 1A2. Unlikely interaction with protease inhibitors. In one reported test-tube study, cocaine made HIV reproduce 20 times faster than normal.

Alcohol: Metabolized by alcohol dehydrogenase, aldehype hydrogenase; may induce p450 3A and 2E1 (minor). Avoid or use moderately. Causes dehydration; drink a lot of water.

I thought this interesting, http://www.aidsinfonyc.org/hivplus/i...head/p450.html
Look down to the steroids, I also thought that the grapefruit juice was interesting too.
I remember cookie talking about that once.

17-09-2005, 02:27 PM	#11 (permalink)
hackskii UK-Muscle Moderator Join Date: Jul 2003 Location: Sunny Southern California U.S.A. Posts: 23,654	Just found this P450 Metabolism Managing Drug Interactions Today, there are several updated p450 pharmacology charts on the Internet to help health providers assess potential drug interactions. The following chart tells you what p450 liver pathway is used by a given drug. If two drugs use the same pathway, they could affect one another. In general, a P450 substrate is any drug that uses the cytochrome p450 enzyme pathway. P450 inhibitors (INH) generally increase concentrations of other drugs. P450 inducers (IND) generally decrease concentrations of other drugs. P450 enzymes are classified using Roman numerals and letters. Almost half of all human drugs use p450 3A4; another 30 percent use p450 2D6. Explanation of Table: P450 substrate (S) is any drug that uses the Cytochrome p450 enzyme pathway. P450 inhibitors (INH) generally increase concentrations of other drugs. P450 inducers (IND) generally decrease concentrations of other drugs. Some HIV drugs are both inducers and inhibitors. Marijuana/Marinol: Uses p450 3A4, 2C9, 2C6 liver pathways. Specific interactions unknown. Cocaine: Uses p450 liver pathways: Minor 2D6 inhibitor, 3A4 inducer, 2B1, 1A2. Unlikely interaction with protease inhibitors. In one reported test-tube study, cocaine made HIV reproduce 20 times faster than normal. Alcohol: Metabolized by alcohol dehydrogenase, aldehype hydrogenase; may induce p450 3A and 2E1 (minor). Avoid or use moderately. Causes dehydration; drink a lot of water. I thought this interesting, http://www.aidsinfonyc.org/hivplus/i...head/p450.html Look down to the steroids, I also thought that the grapefruit juice was interesting too. I remember cookie talking about that once. __________________ "Life is not measured by the number of breaths we take, but by the moments that take our breath away." - George Carlin Scott To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.